Kainic acid，prototypic kainate receptor激动剂(ab120100)
Key features and details
- Prototypic kainate receptor agonist
- CAS Number: 487-79-6
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Digenea simplex
概述
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产品名称
Kainic acid，prototypic kainate receptor激动剂 -
描述
Prototypic kainate receptor激动剂 -
别名
- Kainate
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生物学描述
Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states. Also available in Kit(s): Ionotropic agonists (ab120323).
Also available in simple stock solutions (ab144490) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
487-79-6 -
化学结构
性能
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化学名称
(2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid -
分子量
213.23 -
分子式
C10H15NO4 -
PubChem识别号
10255 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 25 mM -
处理
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O -
来源
Digenea simplex
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120100于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (68)
ab120100 被引用在 68 文献中.
- Melin E et al. Combinatorial gene therapy for epilepsy: Gene sequence positioning and AAV serotype influence expression and inhibitory effect on seizures. Gene Ther 30:649-658 (2023). PubMed: 37029201
- Fan J et al. Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy. CNS Neurosci Ther 29:2884-2900 (2023). PubMed: 37072932
- Wu J et al. Principal neurons in the olfactory cortex mediate bidirectional modulation of seizures. J Physiol 601:3557-3584 (2023). PubMed: 37384845
- Skrabak D et al. Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing. Commun Biol 6:1029 (2023). PubMed: 37821582
- Špirková A et al. Glutamate can act as a signaling molecule in mouse preimplantation embryos†. Biol Reprod 107:916-927 (2022). PubMed: 35746896