K252a,蛋白and CAM kinase抑制剂(ab120419)
Key features and details
- Highly potent inhibitor of protein and CAM kinases
- CAS Number: 99533-80-9
- Purity: > 98%
- Soluble in DMSO to 25 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Nocardiopsis sp.
概述
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产品名称
K252a,蛋白and CAM kinase抑制剂 -
描述
Highly potent抑制剂of蛋白and CAM kinases -
生物学描述
Highly potent, cell-permeable inhibitor of protein kinases such as PKA, PKC, PKG (IC50 = 18-25 nM), Serine/threonine protein kinases (IC50 values are 10-20 nM) and CAM kinase II (Ki = 1.8 nM). Analog of staurosporine (ab120056), exhibits a wide range of effects including neuroprotection and improvement of psoriasis in vivo.
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纯度
> 98% -
CAS编号
99533-80-9 -
化学结构
性能
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化学名称
(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester -
分子量
467.48 -
分子式
C27H21N3O5 -
PubChem识别号
3035817 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 25 mM and in ethanol to 5 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OC)[C@@]8(O)C[C@H]7O[C@]8(C)n4c3c1n7c6ccccc6c1c2c(CNC2=O)c3c5ccccc45 -
来源
Nocardiopsis sp.
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研究领域
图片
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Chemical Structure - K252a, protein and CAM kinase inhibitor (ab120419)2D chemical structure image of ab120419, K252a, protein and CAM kinase inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120419 被引用在 3 文献中.
- Xiong J et al. A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin. Nat Commun 13:4820 (2022). PubMed: 35973996
- Rizzi C et al. NGF steers microglia toward a neuroprotective phenotype. Glia 66:1395-1416 (2018). PubMed: 29473218
- Liang F et al. Direct Tracking of Amyloid and Tu Dynamics in Neuroblastoma Cells Using Nanoplasmonic Fiber Tip Probes. Nano Lett 16:3989-94 (2016). PubMed: 27266855