ISRIB (trans-isomer) (ab273604)
Key features and details
- Potent and selective PERK inhibitor
- CAS Number: 1597403-47-8
- Purity: > 96%
Soluble in DMSO to 10 mM with gentle warming
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
ISRIB (trans-isomer) -
描述
Potent and selective PERK 抑制剂 -
生物学描述
Potent and selective PERK inhibitor with IC50 of 5 nM. Integrated stress response (ISR) inhibitor.
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纯度
> 96% -
CAS编号
1597403-47-8 -
化学结构
性能
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化学名称
N,N'-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
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分子量
451.34 -
分子式
C22H24Cl2N2O4 -
PubChem识别号
1011240 -
存放说明
Shipped at room temperature. Store at -20°C. -
溶解度概述
Soluble in DMSO to 10 mM with gentle warming
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处理
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl -
来源
Synthetic
图片
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Chemical Structure - ISRIB (trans-isomer) (ab273604)
Chemical structure of ISRIB (trans-isomer), 1597403-47-8
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (3)
ab273604 被引用在 3 文献中.
- Sekine Y et al. Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound. Science 348:1027-30 (2015). PubMed: 25858979
- Hinnebusch AG Cell biology. Blocking stress response for better memory? Science 348:967-8 (2015). PubMed: 26023119
- Sidrauski C et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife 2:e00498 (2013). PubMed: 23741617
