Ispinesib (SB-715992) (ab273521)
Key features and details
- Potent, selective and reversible allosteric inhibitor of KSP
- CAS Number: 336113-53-2
- Purity: > 98%
Soluble in DMSO to 50 mM and ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Ispinesib (SB-715992) -
描述
Potent，selective and reversible allosteric抑制剂of KSP -
别名
- SB-715992
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生物学描述
A potent, selective and reversible allosteric inhibitor of KSP with IC50 value of 0.5 nM. Often combines with chemotherapy drugs to tumor treatment.
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纯度
> 98% -
CAS编号
336113-53-2 -
化学结构
性能
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化学名称
N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2- quinazolinyl]-2-methylpropyl]-4-methylbenzamide
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分子量
517.06 -
分子式
C30H33ClN4O2 -
PubChem识别号
6851740 -
存放说明
Shipped at 4°C. Store at -20°C. -
溶解度概述
Soluble in DMSO to 50 mM and ethanol to 100 mM
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处理
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C -
来源
Synthetic
图片
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Chemical Structure - Ispinesib (SB-715992) (ab273521)
Chemical structure of Ispinesib (SB-715992), 336113-53-2
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab273521 被引用在 4 文献中.
- Purcell JW et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res 16:566-76 (2010). PubMed: 20068098
- Carol H et al. Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer 53:1255-63 (2009). PubMed: 19554570
- Lad L et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry 47:3576-85 (2008). PubMed: 18290633
- Davis DA et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer 6:22 (2006). PubMed: 16433906