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AB146155

Importazole,核transport receptor importin-beta抑制剂

Importazole, nuclear transport receptor importin-beta inhibitor

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(1 Publication)

MW 318.42 g/mol, Purity >99%. Selective nuclear transport receptor importin-β inhibitor (IC50 = 25 μM). Blocks SINC localization at the nuclear envelope. Impairs release of importin-β cargo and induces defects in defects in spindle assembly during mitosis.
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Chemical Structure - Importazole, nuclear transport receptor importin-beta inhibitor (AB146155)
  • Chemical Structure

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Chemical Structure - Importazole, nuclear transport receptor importin-beta inhibitor (AB146155)

2D chemical structure image of ab146155, Importazole, nuclear transport receptor importin-beta inhibitor

关键信息

CAS 号

662163-81-7

纯度

>99%

形式

Solid

form

分子量

318.42 g/mol

分子式

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>2</sub>N<sub>4</sub>

属性

Synthetic

溶解度

Soluble in ethanol to 25 mM

Soluble in DMSO to 100 mM

生物学描述

Selective nuclear transport receptor importin-β inhibitor (IC50 = 25 μM). Blocks SINC localization at the nuclear envelope. Impairs release of importin-β cargo and induces defects in defects in spindle assembly during mitosis.

经典 SMILES

CC(NC1NC(NC2CCCCC12)N3CCCC3)C4CCCCC4

InChi

InChI=1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)

InChiKey

HKGJEZIGDHFJFL-UHFFFAOYSA-N

IUPAC 名

N-(1-Phenylethyl)-2-(1-pyrrolidinyl)-4-quinazolinamine

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搭配使用产品

Biochemicals

AB120630

Nocodazole, Microtubule inhibitor

Immunoprecipitation - Nocodazole, Microtubule inhibitor (AB120630)

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Biochemicals

AB120501

Leptomycin B (ethanol solution), Antibiotic, antifungal. Inhibitor of CRM-1 mediated nuclear export.

Functional Studies - Leptomycin B (ethanol solution), Antibiotic, antifungal. Inhibitor of CRM-1 mediated nuclear export. (AB120501)

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Assay Kits

AB178013

Human IL-6 ELISA Kit

KO Validated|Recombinant|SimpleStep

Sandwich ELISA - Human IL-6 ELISA Kit (AB178013)

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Primary Antibodies

AB307438

Anti-Importin subunit alpha antibody [EPR26346-53]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Importin subunit alpha antibody [EPR26346-53] (AB307438)

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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
储存信息
The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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产品实验方案

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Aging cell 18:e13035 PubMed31532069

2019

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration.

Applications

Unspecified application

Species

Unspecified reactive species

Mauro Montalbano,Salome McAllen,Urmi Sengupta,Nicha Puangmalai,Nemil Bhatt,Anna Ellsworth,Rakez Kayed
View all publications
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