Ifenprodil hemitartrate，GluN2B (formerly NR2B)-preferring NMDA拮抗剂(ab120111)
Key features and details
- GluN2B (formerly NR2B)-preferring NMDA antagonist
- CAS Number: 23210-58-4
- Soluble in water to 15 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Ifenprodil hemitartrate，GluN2B (formerly NR2B)-preferring NMDA拮抗剂 -
描述
GluN2B (formerly NR2B)-preferring NMDA拮抗剂 -
生物学描述
Non-competitive NMDA receptor antagonist acting at the polyamine site. Displays GluN2B (formerly NR2B) subunit selectivity. IC50 values are 0.15 μM at NR1/NR2B and >30 μM for NR1/NR2A, NR1/NR2C and NR1/NR2D receptors.
Also available in simple stock solutions (ab146675) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
23210-58-4 -
化学结构
性能
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化学名称
erythro-4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemitartrate -
分子量
400.49 -
分子式
C21H27NO2.0.5C4H6O6 -
PubChem识别号
656586 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 15 mM and in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O -
来源
Synthetic
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研究领域
相关产品
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图片
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Chemical Structure - Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist (ab120111)2D chemical structure image of ab120111, Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist
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Functional Studies - Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist (ab120111)Image from Case DT et al., PLoS One. 2011;6(6):e20756. Fig 4(D).; doi: 10.1371/journal.pone.0020756. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Median ifenprodil sensitivity from a rat postnatal day 2 (P2) and day 12 (P12) neuron; NMDAR-mediated responses in control (black) and in presence of the GluN2B-preferring antagonist ifenprodil (ab120111, grey).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (11)
ab120111 被引用在 11 文献中.
- Li Y et al. Chronic Blockade of NMDAR Subunit 2A in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension through Suppression of MEK/ERK/CREB Pathway. Am J Hypertens N/A:N/A (2021). PubMed: 33856436
- Taoro-Gonzalez L et al. Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms. J Neuroinflammation 15:36 (2018). PubMed: 29422059
- Yu YJ et al. Involvement of protein phosphatases in the destabilization of methamphetamine-associated contextual memory. Learn Mem 23:486-93 (2016). PubMed: 27531839
- Yang Y & Xu-Friedman MA Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus. J Neurophysiol 113:3634-45 (2015). PubMed: 25855696
- Tovar KR et al. Triheteromeric NMDA receptors at hippocampal synapses. J Neurosci 33:9150-60 (2013). PubMed: 23699525