Herkinorin，mu opioid激动剂(ab120147)
Key features and details
- Non-internalising μ opioid agonist
- CAS Number: 862073-77-6
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Herkinorin，mu opioid激动剂 -
描述
Non-internalising μ opioid激动剂 -
生物学描述
Selective μ opioid receptor agonist derived from the plant product, salvinorin A (ab120084). Does not promote the recruitment of beta-arrestin-2 or lead to receptor internalization.
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CAS编号
862073-77-6 -
化学结构
性能
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化学名称
(2S,4aR,6aR,7R,9S,10aS,10bR)-Methyl 9-(benzoyloxy)-2-(furan-3-yl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-1H-benzo[f]isochromene-7-carboxylate -
分子量
494.53 -
分子式
C28H30O8 -
PubChem识别号
11431898 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OC)[C@@H]5C[C@H](OC(=O)c1ccccc1)C(=O)[C@H]2[C@@]5(C)CC[C@H]3C(=O)O[C@@H](C[C@]23C)c4ccoc4 -
来源
Synthetic
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研究领域
相关产品
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Related Products
图片
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Chemical Structure - Herkinorin, mu opioid agonist (ab120147)2D chemical structure image of ab120147, Herkinorin, mu opioid agonist
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Immunocytochemistry/ Immunofluorescence - Herkinorin, mu opioid agonist (ab120147)Image from Rowan, Matthew P et al., PLOS One., 9(4): e93688. Fig 1 A and D.; doi: 10.1371/journal.pone.0093688 Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Primary sensory neurons treated with vehicle (0.1% DMSO) (top panel) and 10 μM of ab120147 for 15 minutes (bottom panel) revealed no significant difference in CFP emission. It does not recruit β-arrestin2 to MOPr in primary sensory neurons.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120147 被引用在 4 文献中.
- Casteels T et al. An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation. Mol Metab 54:101329 (2021). PubMed: 34454092
- Rowan MP et al. Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via ß-arrestin-2-mediated cross-talk. PLoS One 9:e93688 (2014). PubMed: 24695785
- Ji F et al. Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) in a piglet model. Brain Res 1490:95-100 (2013). PubMed: 23103502
- Cui X et al. Ligand interaction, binding site and G protein activation of the mu opioid receptor. Eur J Pharmacol 702:309-15 (2013). PubMed: 23415745