HENECA，A2A receptor激动剂(ab120458)
Key features and details
- Selective A2A receptor agonist
- CAS Number: 141018-30-6
- Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
HENECA，A2A receptor激动剂 -
描述
Selective A2A receptor激动剂 -
生物学描述
Selective A2A receptor agonist (Ki = 2.2 nM). Shows good selectivity for A2A over A1 receptors. Displays antiaggregatory activity. Increases cAMP accumulation (EC50 = 43 nM) and inhibits superoxide anion production (EC50 = 3.63 nM) in neutrophils.
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CAS编号
141018-30-6 -
化学结构
性能
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化学名称
2-Hexynyladenosine-5'-N-ethylcarboxamide -
分子量
388.42 -
分子式
C18H24N6O4 -
PubChem识别号
4438292 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating) -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCNC(=O)C3OC(n2cnc1c(N)nc(C#CCCCC)nc12)C(O)C3O -
来源
Synthetic
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研究领域
图片
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Chemical Structure - HENECA, A2A receptor agonist (ab120458)2D chemical structure image of ab120458, HENECA, A2A receptor agonist
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Cellular activation - HENECA, A2A receptor agonist (ab120458)Image from Nagpure B V, et al. Plos One, 9(2), e88508. Fig 1a,; doi: 10.1371/journal.pone.0088508Concentration-dependent effect of HENECA (10-200 nM, 24 hours) on Aβ42 production.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120458 被引用在 1 文献中.
- Nagpure BV & Bian JS Hydrogen sulfide inhibits A2A adenosine receptor agonist induced ß-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway. PLoS One 9:e88508 (2014). PubMed: 24523906