GSK 0660, PPARdelta antagonist

关键信息

CAS 号

1014691-61-2

纯度

>99%

形式

Solid

form

分子量

418.5 Da

分子式

C₁₉H₁₈N₂O₅S₂

PubChem

46233311

属性

Synthetic

溶解度

Soluble in DMSO to 100 mM

生化试剂名称

Methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate

生物学描述

Selective PPARδ antagonist (IC₅₀ values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ, respectively). Active in vivo. Exhibits inverse agonist effects when administered alone.

经典 SMILES

COC1=C(C=CC(=C1)NC2=CC=CC=C2)NS(=O)(=O)C3=C(SC=C3)C(=O)OC

InChi

InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3

InChiKey

NDFKBGWLUHKMFY-UHFFFAOYSA-N

IUPAC 名

methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate