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GF 109203X hydrochloride，ATP-competitive PKC抑制剂(ab120844)

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Chemical Structure - GF 109203X hydrochloride, ATP-competitive PKC inhibitor (ab120844)

    Key features and details

    • Potent, cell-permeable, ATP-competitive PKC inhibitor
    • CAS Number: 176504-36-2
    • Purity: > 98%
    • Soluble in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      GF 109203X hydrochloride，ATP-competitive PKC抑制剂

    • 描述

      Potent，cell-permeable，ATP-competitive PKC抑制剂

    • 生物学描述

      Potent, cell-permeable, ATP-competitive PKC inhibitor (IC50 values for PKC subtypes are 50 (α), 17 (βI), 16 (βII) and 20 nM (γ)). Inhibits PKC over other kinases (IC50 values are 50 nM (MAPKAP), 100 nM (p70 S6 kinase), 2 μM (cAMP-dependent protein kinase) and 0.7 μM (phosphorylase kinase)). Crosses the blood-brain barrier.

    • 纯度

      > 98%

    • CAS编号

      176504-36-2

    • 化学结构

      Chemical Structure

    性能

    • 化学名称

      3-[1-(Dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride

    • 分子量

      448.95

    • 分子式

      C25H24N4O2.HCl

    • PubChem识别号

      6419775

    • 存放说明

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

    • 溶解度概述

      Soluble in DMSO to 100 mM

    • 处理

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54.Cl

    • 来源

      Synthetic

    • 研究领域

    相关产品

    图片

    • Chemical Structure - GF 109203X hydrochloride, ATP-competitive PKC inhibitor (ab120844)
      Chemical Structure - GF 109203X hydrochloride, ATP-competitive PKC inhibitor (ab120844)
      2D chemical structure image of ab120844, GF 109203X hydrochloride, ATP-competitive PKC inhibitor

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (1)

    发表研究结果有使用 ab120844？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab120844 被引用在 1 文献中.

    • Zhang H  et al. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. J Neurochem 161:478-491 (2022). PubMed: 35583089

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