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AB120607

GBR 12909 dihydrochloride，Dopamine transport抑制剂

GBR 12909 dihydrochloride, Dopamine transport inhibitor

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MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
2 Images
Immunocytochemistry/ Immunofluorescence - GBR 12909 dihydrochloride, Dopamine transport inhibitor (AB120607)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - GBR 12909 dihydrochloride, Dopamine transport inhibitor (AB120607)

ab65783 staining NR2B in SKNSH cells treated with GBR 12909 dihydrochloride (ab120607), by ICC/IF. Decrease in NR2B expression correlates with increased concentration of GBR 12909 dihydrochloride, as described in literature.
The cells were incubated at 37°C for 10 minutes in media containing different concentrations of ab120607 (GBR 12909 dihydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab65783 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - GBR 12909 dihydrochloride, Dopamine transport inhibitor (AB120607)
  • Chemical Structure

Lab

Chemical Structure - GBR 12909 dihydrochloride, Dopamine transport inhibitor (AB120607)

2D chemical structure image of ab120607, GBR 12909 dihydrochloride, Dopamine transport inhibitor

关键信息

CAS 号

67469-78-7

纯度

>98%

形式

Solid

form

分子量

523.5 Da

分子式

C<sub>2</sub><sub>8</sub>H<sub>3</sub><sub>4</sub>Cl<sub>2</sub>F<sub>2</sub>N<sub>2</sub>O

PubChem

104920

属性

Synthetic

溶解度

Soluble in water to 25 mM (with heating)

Soluble in DMSO to 100 mM (with heating)

生化试剂名称

Vanoxerine dihydrochloride

生物学描述

Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).

经典 SMILES

C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl

InChi

InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H

InChiKey

MIBSKSYCRFWIRU-UHFFFAOYSA-N

IUPAC 名

1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride

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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
储存信息
Store under desiccating conditions|The product can be stored for up to 12 months
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产品实验方案

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