Fluvastatin sodium salt，HMG-CoA reductase抑制剂(ab120651)
Key features and details
- Competitive HMG-CoA reductase inhibitor
- CAS Number: 93957-55-2
- Purity: > 99%
- Soluble in DMSO to 100 mM and in water to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Fluvastatin sodium salt，HMG-CoA reductase抑制剂 -
描述
Competitive HMG-CoA reductase抑制剂 -
生物学描述
Competitive HMG-CoA reductase inhibitor (IC50 = 40 - 100 nM in human and rat microsomes). Potent inhibitor of vascular smooth muscle cell proliferation in vitro (IC50 = 70 nM).
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纯度
> 99% -
CAS编号
93957-55-2 -
化学结构
性能
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化学名称
(±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt -
分子量
433.45 -
分子式
C24H25FNNaO4 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in water to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120651于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
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Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - Fluvastatin sodium salt, HMG-CoA reductase inhibitor (ab120651)2D chemical structure image of ab120651, Fluvastatin sodium salt, HMG-CoA reductase inhibitor
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Immunocytochemistry/ Immunofluorescence - Fluvastatin sodium salt, HMG-CoA reductase inhibitor (ab120651)ab90529 staining cytochrome C in HepG2 cells treated with fluvastatin sodium salt (ab120651), by ICC/IF. Increase of cytochrome C expression correlates with increased concentration of fluvastatin sodium salt, as described in literature.
The cells were incubated at 37°C for 48 hours in media containing different concentrations of ab120651 (fluvastatin sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab90529 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120651 被引用在 1 文献中.
- Dorsch M et al. Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis. Cell Rep 37:110056 (2021). PubMed: 34818551