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AB120077

Fluoxetine hydrochloride，5-HT reuptake抑制剂

Fluoxetine hydrochloride, 5-HT reuptake inhibitor

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(6 Publications)

MW 345.8 Da, Purity >99%. Potent, selective 5-HT reuptake inhibitor. Antidepressant in vivo. Binds to rat and human 5-HT transporters with Ki values of 2 and 0.9-20 nM, respectively. Shows around 150-900-fold selectivity over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic and muscarinic receptors.
2 Images
Functional Studies - Fluoxetine hydrochloride, 5-HT reuptake inhibitor (AB120077)
  • FuncS

Unknown

Functional Studies - Fluoxetine hydrochloride, 5-HT reuptake inhibitor (AB120077)

ab66047 staining serotonin in SKNSH cells treated with fluoxetine hydrochloride (ab120077), by ICC/IF. Increase of serotonin expression correlates with increased concentration of fluoxetine hydrochloride, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120077 (fluoxetine hydrochloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66047 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 donkey anti-goat polyclonal antibody (ab96931) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Fluoxetine hydrochloride, 5-HT reuptake inhibitor (AB120077)
  • Chemical Structure

Lab

Chemical Structure - Fluoxetine hydrochloride, 5-HT reuptake inhibitor (AB120077)

2D chemical structure image of ab120077, Fluoxetine hydrochloride, 5-HT reuptake inhibitor

关键信息

CAS 号

56296-78-7

纯度

>99%

形式

Solid

form

分子量

345.8 Da

分子式

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>9</sub>ClF<sub>3</sub>NO

PubChem

62857

属性

Synthetic

溶解度

Soluble in water to 10 mM

Soluble in DMSO to 100 mM

生化试剂名称

Fluoxetine hydrochloride

生物学描述

Potent, selective 5-HT reuptake inhibitor. Antidepressant in vivo. Binds to rat and human 5-HT transporters with Ki values of 2 and 0.9-20 nM, respectively. Shows around 150-900-fold selectivity over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic and muscarinic receptors.

经典 SMILES

CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl

InChi

InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChiKey

GIYXAJPCNFJEHY-UHFFFAOYSA-N

IUPAC 名

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine;hydrochloride

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搭配使用产品

Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

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Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

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  • 8
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

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Biochemicals

AB120133

Citalopram, 5-HT reuptake inhibitor

Chemical Structure - Citalopram, 5-HT reuptake inhibitor (AB120133)

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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
储存信息
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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产品实验方案

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Molecular psychiatry 29:1046-1062 PubMed38233467

2024

High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin.

Applications

Unspecified application

Species

Unspecified reactive species

Dotan Braun,Ayelet M Rosenberg,Elad Rabaniam,Ravid Haruvi,Dorel Malamud,Rani Barbara,Tomer Aiznkot,Berta Levavi-Sivan,Takashi Kawashima

Current protocols 1:e208 PubMed34406704

2021

Models of Depression: Unpredictable Chronic Mild Stress in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mathieu Nollet

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:13619-28 PubMed26446216

2015

Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features.

Applications

Unspecified application

Species

Unspecified reactive species

M Isabel Aller,Valeria Pecoraro,Ana V Paternain,Santiago Canals,Juan Lerma

Journal of psychopharmacology (Oxford, England) 27:192-202 PubMed23118019

2012

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Joseph J Casal-Dominguez,Mary Clark,John R Traynor,Stephen M Husbands,Sarah J Bailey

The Journal of general physiology 135:333-53 PubMed20231374

2010

P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.

Applications

Unspecified application

Species

Unspecified reactive species

Estelle Toulme,Angie Garcia,Damien Samways,Terrance M Egan,Monica J Carson,Baljit S Khakh

Neuroscience 167:456-74 PubMed20167261

2010

Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

S D Greenhill,R S G Jones
View all publications
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