Flumazenil，Benzodiazepine拮抗剂(ab120242)
Key features and details
- Benzodiazepine antagonist
- CAS Number: 78755-81-4
- Purity: > 99%
- Soluble in DMSO to 25 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Flumazenil，Benzodiazepine拮抗剂 -
描述
Benzodiazepine拮抗剂 -
别名
- Ro 15-1788
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生物学描述
Selective non-competitive benzodiazepine antagonist with low affinity for α4- and α6-subunits
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纯度
> 99% -
CAS编号
78755-81-4 -
化学结构
性能
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化学名称
8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1 ,4]benzodiazepine-3-carboxylic acid ethyl ester -
分子量
303.29 -
分子式
C15H14FN3O3 -
PubChem识别号
3373 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 25 mM and in ethanol to 5 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OCC)c3ncn2c3CN(C)C(=O)c1cc(F)ccc12 -
来源
Synthetic
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研究领域
- Biochemicals
- Pharmacology
- Receptors & Transporters
- GABA
- GABAA
- Benzodiazepine Site
- Antagonists / inverse agonists
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipases
- Biochemicals
- Research Area
- Pain & inflammation
- GABA
- GABAA
- Benzodiazepine Site
- Antagonists / inverse agonists
相关产品
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Alternative Versions
图片
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Chemical Structure - Flumazenil, Benzodiazepine antagonist (ab120242)2D chemical structure image of ab120242, Flumazenil, Benzodiazepine antagonist
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Functional Studies - Flumazenil, Benzodiazepine antagonist (ab120242)Jin et al PLoS One. 2011; 6(1): e16188. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Inhibition of insulin (1 nM) induced tonic current by flumazenil and zolpidem.
Effects of flumazenil (1 µM) on the currents in an ACSF (a) and an insulin treated neuron (b).
(From Figure 2A of Jin et al).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120242 被引用在 3 文献中.
- Jin Z et al. Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current. PLoS One 6:e16188 (2011). PubMed: 21264261
- Amato RJ et al. Effects of pregnanolone and flunitrazepam on the retention of response sequences in rats. Pharmacol Biochem Behav 99:391-8 (2011). PubMed: 21640749
- Amato RJ et al. Effects of positive and negative modulators of the ?-aminobutyric acid A receptor complex on responding under a differential-reinforcement-of-low-rate schedule of reinforcement in rats. Behav Pharmacol : (2010). PubMed: 20838210