Fludarabine (FAMP)，DNA synthesis抑制剂(ab141048)
Key features and details
- DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A.
- CAS Number: 21679-14-1
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Fludarabine (FAMP)，DNA synthesis抑制剂 -
描述
DNA synthesis抑制剂. Prodrug converted to active metabolite F-ara-A. -
生物学描述
DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A which inhibits ribonucleotide reductase and competitively inhibits DNA polymerase. Also prevents DNA ligase I from joining DNA. Induces apoptosis. Active in vivo.
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纯度
> 98% -
CAS编号
21679-14-1 -
化学结构
性能
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化学名称
9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine -
分子量
285.23 -
分子式
C10H12FN5O4 -
PubChem识别号
8975 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Nc3nc(F)nc2c3ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O -
来源
Synthetic
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研究领域
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
图片
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Chemical Structure - Fludarabine (FAMP), DNA synthesis inhibitor (ab141048)2D chemical structure image of ab141048, Fludarabine (FAMP), DNA synthesis inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
ab141048 尚未被引用在任何文献中。