Flecainide，Sodium channel blocker (ab120504)
Key features and details
- Sodium channel blocker
- CAS Number: 54143-55-4
- Soluble in ethanol to 100 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Flecainide，Sodium channel blocker -
描述
Sodium channel blocker -
生物学描述
Sodium channel blocker. Class IC antiarrhythmic agent. Inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Also inhibits cardiac ryanodine receptors. Orally-active.
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CAS编号
54143-55-4 -
化学结构
性能
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化学名称
(RS)-N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide -
分子量
414.34 -
分子式
C17H20F6N2O3 -
PubChem识别号
3356 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 100 mM and in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
FC(F)(F)COc2cc(C(=O)NCC1CCCCN1)c(OCC(F)(F)F)cc2 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Flecainide, Sodium channel blocker (ab120504)2D chemical structure image of ab120504, Flecainide, Sodium channel blocker
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab120504 被引用在 2 文献中.
- Jæger KH et al. Identifying Drug Response by Combining Measurements of the Membrane Potential, the Cytosolic Calcium Concentration, and the Extracellular Potential in Microphysiological Systems. Front Pharmacol 11:569489 (2020). PubMed: 33628168
- Streit J & Kleinlogel S Dynamic all-optical drug screening on cardiac voltage-gated ion channels. Sci Rep 8:1153 (2018). PubMed: 29348631