Esomeprazole sodium，H+/ K+-ATPase (proton pump)抑制剂(ab120500)
Key features and details
- H+/ K+-ATPase (proton pump) inhibitor
- CAS Number: 161796-78-7
- Soluble in water to 100 mM, in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Esomeprazole sodium，H+/ K+-ATPase (proton pump)抑制剂 -
描述
H+/ K+-ATPase (proton pump)抑制剂 -
生物学描述
H+ / K+-ATPase (proton pump) inhibitor (IC50 = 2.3 µM). S-enantiomer of omeprazole. Attenuates intestinal mucosal barrier damage and can promote healing of gastric lesions in rats. Also inhibits Cytochrome P450 2C19 (CYP2C9), CYP2C19 and CYP3A4 (Ki values are 81.5, 8.6 and 46.6 µM, respectively).
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CAS编号
161796-78-7 -
化学结构
性能
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化学名称
6-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt -
分子量
367.40 -
分子式
C17H18N3NaO3S -
PubChem识别号
23674541 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM, in ethanol to 100 mM and in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Na+].Cc3c(OC)c(C)cnc3CS(=O)c1[n-]c2cc(ccc2n1)OC -
来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120500于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
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Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor (ab120500)2D chemical structure image of ab120500, Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor
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Functional Studies - Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor (ab120500)MDA-MB-231 cells were incubated at 37°C for 6h with vehicle control (0 µM) and 100 µM of esomeprazole sodium (ab120500). Increased expression of aryl hydrocarbon receptor (ab2770) correlates with an increase in esomeprazole sodium concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab2770 at 2 µg/ml and ab8226 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-mouse antibody conjugated to HRP (ab97040) at 1/10000 dilution and visualised using ECL development solution.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
ab120500 尚未被引用在任何文献中。