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AB209693

Erastin，ferroptosis活化剂

Erastin, ferroptosis activator

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(5 Publications)

MW 547 Da, Purity >98%. Selective ferroptosis activator. Induces RAS-RAF-MEK-dependent non-apoptotic cell death via VDAC2 (IC50 = 0.1 μM).

查看别名

Amino acid transport system xc xCT antibody, Amino acid transport system xc-, B-36 vdac, C BAS/HAS, C HA RAS1, CCBR1, CTLO, Calcium channel blocker resistance protein CCBR1, Calcium channel blocker resistance protein CCBR1 antibody, Cysteine/glutamate transporter antibody, Cystine/glutamate transporter, FLJ23841, GTP and GDP binding peptide B, GTPase HRas, N-terminally processed, H RASIDX, H-Ras-1, HAMSV, HRAS, Ha Ras1 proto oncoprotein, Ha-Ras, Harvey rat sarcoma viral oncogene homolog, Harvey rat sarcoma viral oncoprotein, IF 1, IFG, IFI, IFN immune, IFN-gamma, IFNG_HUMAN, Immune interferon, Interferon gamma, K ras, N ras, OTTHUMP00000019878, OTTHUMP00000019879, OTTHUMP00000019880, OTTHUMP00000164578, Outer mitochondrial membrane protein porin 2, POR, Porin-2, RASH1, RASH_HUMAN, Ras family small GTP binding protein H Ras, SLC7A11, SYSTEM Xc(-) TRANSPORTER-RELATED PROTEIN, Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11, Solute carrier family 7 member 11, Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, Transformation gene oncogene HAMSV, Transforming protein p21, Type II Interferon, VDAC2_HUMAN, VH Ras, Vdac6, Voltage dependent anion channel 2, Voltage-dependent anion-selective channel protein 2, XCT_HUMAN, c has/bas p21 protein, c ras Ki 2 activated oncogene, c-H-ras, hVDAC2, p19 H RasIDX protein, p21ras, solute carrier family 7, v Ha ras Harvey rat sarcoma viral oncogene homolog, vHa RAS

1 Images
Chemical Structure - Erastin, ferroptosis activator (AB209693)
  • Chemical Structure

Unknown

Chemical Structure - Erastin, ferroptosis activator (AB209693)

2D chemical structure image of ab209693, Erastin, ferroptosis activator

关键信息

CAS 号

571203-78-6

纯度

>98%

形式

Solid

form

分子量

547 Da

分子式

C<sub>3</sub><sub>0</sub>H<sub>3</sub><sub>1</sub>ClN<sub>4</sub>O<sub>4</sub>

PubChem

11214940

属性

Synthetic

溶解度

Soluble in DMSO to 20 mM

生化试剂名称

Erastin

生物学描述

Selective ferroptosis activator. Induces RAS-RAF-MEK-dependent non-apoptotic cell death via VDAC2 (IC50 = 0.1 μM).

经典 SMILES

CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl

InChi

InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChiKey

BKQFRNYHFIQEKN-UHFFFAOYSA-N

IUPAC 名

2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one

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产品详情

This product is manufactured by BioVision, an Abcam company and was previously called 2231 Erastin. 2231-5 is the same size as the 5 mg size of ab209693.
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性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
It is important to note that this product is reported to be light sensitive|Store under desiccating conditions
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Interferon gamma (IFN-γ) GTPase HRAS VDAC2 and xCT represent significant proteins each with unique mechanical functions. IFN-γ a cytokine with a molecular weight of approximately 17 kDa is primarily expressed in activated T cells and natural killer cells. It is recognized as a critical mediator in immune response stimulating other immune cells. HRAS a small GTPase weighs about 21 kDa and plays an important role in signal transduction by cycling between inactive GDP-bound and active GTP-bound states. It is ubiquitously expressed in many tissues. VDAC2 with a molecular mass of around 32 kDa is part of the voltage-dependent anion channel family located in the outer mitochondrial membrane. Meanwhile xCT also known as the solute carrier family 7 member 11 (SLC7A11) is an important component of the system Xc- responsible for cystine-glutamate exchange primarily expressed in the brain kidney and placenta.
Biological function summary

The activities of these proteins contribute significantly to cellular processes and homeostasis. IFN-γ's main role involves modulation of the immune system by enhancing antigen presentation and promoting macrophage activation. HRAS is part of multiple protein complexes that dictate cellular proliferation and differentiation through its role in the MAPK and PI3K/AKT pathways. VDAC2 is essential for metabolite transport between the mitochondria and cytoplasm and its functions are tightly linked with mitochondrial apoptosis regulation. xCT's activity as part of a transporter complex helps maintain redox balance and prevent oxidative stress by importing cystine which can be converted to cysteine for glutathione biosynthesis an important antioxidant.

Pathways

These proteins contribute to distinct yet interconnected biological routes. IFN-γ is a critical player in the JAK-STAT signaling pathway which influences immune and inflammatory responses. HRAS’s involvement in the MAPK and PI3K/AKT pathways links it directly with cell growth and survival. VDAC2 plays an integral role in apoptosis pathways by interacting with apoptotic regulators like Bcl-2 family proteins thereby promoting or inhibiting cell death. xCT is a central part of the ferroptosis pathway due to its role in supplying cysteine for glutathione production and its activity is particularly relevant when discussing cell death linked to oxidative damage and ferroptosis markers.

These proteins are associated with various pathological conditions. IFN-γ has a significant connection with autoimmune and infectious diseases such as rheumatoid arthritis where its overexpression leads to excessive inflammation. HRAS on the other hand is well-known in oncology for its mutations that drive certain types of cancer including bladder cancer. VDAC2 by influencing apoptosis has implications in neurodegenerative diseases like Alzheimer’s commonly involving interactions with amyloid-beta. xCT is linked to cancer and neurodegeneration through its role in regulating ferroptosis; its interaction with proteins like GPX4 a known inhibitor of ferroptosis highlights its significance in controlling cell fate in disease contexts.
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产品实验方案

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 12:739039 PubMed35185859

2022

Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Lijie Chen,Xing Niu,Xue Qiao,Sai Liu,Hongmei Ma,Xueqing Shi,Xuemei He,Ming Zhong

Cell death and differentiation 23:369-79 PubMed26794443

2016

Ferroptosis: process and function.

Applications

Unspecified application

Species

Unspecified reactive species

Y Xie,W Hou,X Song,Y Yu,J Huang,X Sun,R Kang,D Tang

Biochemical pharmacology 105:14-22 PubMed26774450

2016

Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Christina Haß,Katharina Belz,Hannah Schoeneberger,Simone Fulda

The Biochemical journal 473:769-77 PubMed26759376

2016

An essential role for functional lysosomes in ferroptosis of cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Seiji Torii,Ryosuke Shintoku,Chisato Kubota,Makoto Yaegashi,Ryoko Torii,Masaya Sasaki,Toshinobu Suzuki,Masanobu Mori,Yuhei Yoshimoto,Toshiyuki Takeuchi,Keiichi Yamada

Journal of bioenergetics and biomembranes 40:213-7 PubMed18704666

2008

Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents.

Applications

Unspecified application

Species

Unspecified reactive species

Eriko Simamura,Hiroki Shimada,Toshihisa Hatta,Kei-Ichi Hirai
View all publications
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