E-4031 dihydrochloride，HERG K+ channel blocker (ab120158)
Key features and details
- HERG K+ channel blocker
- CAS Number: 113559-13-0
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
E-4031 dihydrochloride，HERG K+ channel blocker -
描述
HERG K+ channel blocker -
别名
- E4031
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生物学描述
Type III antiarrhythmic drug that blocks ion channels encoded by the ether-a-go-go related gene (ERG1 or KCNH1). Blocks channels in the open configuration with little effect on the channels in the closed configuration. The IC50 for block of human ERG channels in expression systems is approx. 350 nM.
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CAS编号
113559-13-0 -
化学结构
性能
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化学名称
N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride -
分子量
474.44 -
分子式
C21H27N3O3S.2HCl -
PubChem识别号
3087190 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.CS(=O)(=O)Nc1ccc(cc1)C(=O)C3CCN(CCc2cccc(C)n2)CC3 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - E-4031 dihydrochloride, HERG K+ channel blocker (ab120158)2D chemical structure image of ab120158, E-4031 dihydrochloride, HERG K+ channel blocker
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab120158 被引用在 3 文献中.
- Zhang F et al. High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus. Front Cell Dev Biol 10:1038867 (2022). PubMed: 36274846
- Fukushiro-Lopes DF et al. Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer. Oncotarget 9:3321-3337 (2018). PubMed: 29423049
- Greenwood IA et al. Loss of functional K+ channels encoded by ether-à-go-go-related genes in mouse myometrium prior to labour onset. J Physiol 587:2313-26 (2009). PubMed: 19332483