DRB (Benzimidazole)，Casein kinase II抑制剂(ab120939)
Key features and details
- Casein kinase II inhibitor
- CAS Number: 53-85-0
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
DRB (Benzimidazole)，Casein kinase II抑制剂 -
描述
Casein kinase II抑制剂 -
别名
- Benzimidazole
- DiCl-RB
- NSC 401575
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生物学描述
Casein kinase II inhibitor (Ki values are 23 and 48 μM for CKII and CKI, respectively). Inhibitor of RNA polymerase II transcription in vitro and in vivo. Shown to inhibit cyclin C/CDK8 (IC50 = 17 μM) and cyclin H/CDK7/p38 (IC50 = 18 μM) signaling. -
纯度
> 98% -
CAS编号
53-85-0 -
化学结构
性能
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化学名称
5,6-Dichloro-1-β-D-ribofuranosyl-1H-benzimidazole -
分子量
319.14 -
分子式
C12H12Cl2N2O4 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2cc(Cl)c(Cl)cc12 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - DRB (Benzimidazole), Casein kinase II inhibitor (ab120939)2D chemical structure image of ab120939, DRB (Benzimidazole), Casein kinase II inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab120939 被引用在 3 文献中.
- Lu JY et al. Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation. Cell Rep 30:3296-3311.e5 (2020). PubMed: 32160538
- Bi X et al. RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control. Mol Cell 75:102-116.e9 (2019). PubMed: 31128943
- Faust TB et al. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife 7:N/A (2018). PubMed: 29845934