Dorsomorphin (Compound C)，AMP-kinase抑制剂(ab120843)
Key features and details
- Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
- CAS Number: 866405-64-3
- Purity: > 99%
- Soluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating)
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Dorsomorphin (Compound C)，AMP-kinase抑制剂 -
描述
Potent，selective and reversible AMP-kinase抑制剂. Selective for BMP signaling. -
别名
- Compound C
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生物学描述
Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821) -
纯度
> 99% -
CAS编号
866405-64-3 -
化学结构
性能
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化学名称
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine -
分子量
399.49 -
分子式
C24H25N5O -
PubChem识别号
11524144 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating) -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Please note that sonication in a 55 °C water bath is necessary for dissolution of ab120843 in DMSO to 10 mM.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
c1c(cnc2c(cnn12)c3ccncc3)c5ccc(OCCN4CCCCC4)cc5 -
来源
Synthetic
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研究领域
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
图片
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Chemical Structure - Dorsomorphin (Compound C), AMP-kinase inhibitor (ab120843)2D chemical structure image of ab120843, Dorsomorphin (Compound C), AMP-kinase inhibitor
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Functional Studies - Dorsomorphin (Compound C), AMP-kinase inhibitor (ab120843)Li et al PLoS One. 2015 Sep 23;10(9):e0138390. doi: 10.1371/journal.pone.0138390. eCollection 2015. Fig 6. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/G9a inhibition induces autophagy and autophagic cell death through AMPK/mTOR pathway.
T24 cells (Panel G) and UMUC-3 cells (Panel H) were pre-treated with compound C (5 μM) or AICAR (1 mM) and then treated with BIX-01294 (1.5 μM) for 48 h, Cells viability was assessed by MTT assay. *P<0.01.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (51)
ab120843 被引用在 51 文献中.
- Lo L et al. AMPK is required for recovery from metabolic stress induced by ultrasound microbubble treatment. iScience 26:105883 (2023). PubMed: 36685038
- Busch C et al. Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach. Cell Commun Signal 21:342 (2023). PubMed: 38031192
- Liu C et al. Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis. Cell Death Dis 14:707 (2023). PubMed: 37898661
- Liu H et al. Ghrelin alleviates hypoxia/reoxygenation-induced H9C2 injury by activating autophagy and AMPK/ULK1 pathway. Cell Mol Biol (Noisy-le-grand) 69:139-245 (2023). PubMed: 38015515
- Ali Moussa HY et al. Single Extracellular Vesicle Analysis Using Flow Cytometry for Neurological Disorder Biomarkers. Front Integr Neurosci 16:879832 (2022). PubMed: 35655952