Doramapimod，p38 MAPK抑制剂(ab142166)
Key features and details
- Potent, selective, cell permeable p38 MAPK inhibitor
- CAS Number: 285983-48-4
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Doramapimod，p38 MAPK抑制剂 -
描述
Potent，selective，cell permeable p38 MAPK抑制剂 -
别名
- BIRB 796
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生物学描述
Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.
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纯度
> 98% -
CAS编号
285983-48-4 -
化学结构
性能
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化学名称
1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4- ylethoxy)naphthalen-1-yl]urea -
分子量
527.66 -
分子式
C31H37N5O3 -
PubChem识别号
156422 -
存放说明
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Doramapimod, p38 MAPK inhibitor (ab142166)2D chemical structure image of ab142166, Doramapimod, p38 MAPK inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab142166 被引用在 2 文献中.
- Ivshina MP et al. CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia. Glia 70:1850-1863 (2022). PubMed: 35635122
- Lanfranco MF et al. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia 69:1478-1493 (2021). PubMed: 33556209