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Donepezil hydrochloride，Acetylcholinesterase抑制剂(ab120763)

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Chemical Structure - Donepezil hydrochloride, Acetylcholinesterase inhibitor (ab120763)

    Key features and details

    • Acetylcholinesterase inhibitor
    • CAS Number: 120011-70-3
    • Purity: > 99%
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      Donepezil hydrochloride，Acetylcholinesterase抑制剂

    • 描述

      Acetylcholinesterase抑制剂

    • 生物学描述

      Potent, selective acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays >1250 times selectivity for AChE over butyrylcholinesterase. Centrally active. Neuroprotective activity in vitro and in vivo.

    • 纯度

      > 99%

    • CAS编号

      120011-70-3

    • 化学结构

      Chemical Structure

    性能

    • 化学名称

      2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride

    • 分子量

      415.96

    • 分子式

      C24H29NO3.HCl

    • 存放说明

      Store at Room Temperature. The product can be stored for up to 12 months.

    • 溶解度概述

      Soluble in water to 100 mM

    • 处理

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • 来源

      Synthetic

    • 研究领域

    图片

    • Chemical Structure - Donepezil hydrochloride, Acetylcholinesterase inhibitor (ab120763)
      Chemical Structure - Donepezil hydrochloride, Acetylcholinesterase inhibitor (ab120763)
      2D chemical structure image of ab120763, Donepezil hydrochloride, Acetylcholinesterase inhibitor

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (1)

    发表研究结果有使用 ab120763？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab120763 被引用在 1 文献中.

    • Pirollo KF  et al. A Pralidoxime Nanocomplex Formulation Targeting Transferrin Receptors for Reactivation of Brain Acetylcholinesterase After Exposure of Mice to an Anticholinesterase Organophosphate. Int J Nanomedicine 19:307-326 (2024). PubMed: 38229703

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