DNQX disodium salt，AMPA / kainate拮抗剂(ab120169)
Key features and details
- AMPA / kainate antagonist; water soluble
- CAS Number:
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
DNQX disodium salt，AMPA / kainate拮抗剂 -
描述
AMPA / kainate拮抗剂; water soluble -
生物学描述
Water soluble AMPA / kainate antagonist.
Also available in simple stock solutions (ab144496) - add 1 ml of water to get an exact, ready-to-use concentration. -
化学结构
性能
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化学名称
6,7-Dinitroquinoxaline-2,3-dione disodium salt -
分子量
296.11 -
分子式
C8H2N4Na2O6 -
PubChem识别号
45073428 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Na+].[Na+].[O-][N+](=O)c1cc2nc([O-])c([O-])nc2cc1[N+]([O-])=O -
来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120169于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - DNQX disodium salt, AMPA / kainate antagonist (ab120169)2D chemical structure image of ab120169, DNQX disodium salt, AMPA / kainate antagonist
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Functional Studies - DNQX disodium salt, AMPA / kainate antagonist (ab120169)ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with DNQX disodium salt (ab120169), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of DNQX disodium salt, as described in literature.
The cells were incubated at 37°C for 3h in media containing different concentrations of ab120169 (DNQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (14)
ab120169 被引用在 14 文献中.
- Gangal H et al. Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons. Nat Commun 14:3886 (2023). PubMed: 37391566
- Chou MY et al. Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice. Commun Biol 6:267 (2023). PubMed: 36918719
- Fukushima A et al. An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow. Cell Rep 40:111380 (2022). PubMed: 36130511
- Raja MK et al. Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. Elife 8:N/A (2019). PubMed: 31090538
- McIver EL et al. Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons. Cell Rep 28:992-1002.e4 (2019). PubMed: 31340159