DNQX，AMPA / kainate拮抗剂(ab120018)
Key features and details
- AMPA / kainate antagonist
- CAS Number: 2379-57-9
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
DNQX，AMPA / kainate拮抗剂 -
描述
AMPA / kainate拮抗剂 -
生物学描述
AMPA / kainate antagonist
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CAS编号
2379-57-9 -
化学结构
性能
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化学名称
6,7-Dinitroquinoxaline-2,3-dione -
分子量
252.14 -
分子式
C8H4N4O6 -
PubChem识别号
3899541 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further instruction.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O -
来源
Synthetic
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研究领域
相关产品
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Alternative Versions
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120018于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - DNQX, AMPA / kainate antagonist (ab120018)2D chemical structure image of ab120018, DNQX, AMPA / kainate antagonist
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Functional Studies - DNQX, AMPA / kainate antagonist (ab120018)ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with DNQX (ab120018), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of DNQX, as described in literature.
The cells were incubated at 37°C for 1h in media containing different concentrations of ab120018 (DNQX) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (45)
ab120018 被引用在 45 文献中.
- Gu F et al. Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons. Neurobiol Dis 113:45-58 (2018). PubMed: 29408225
- Radzicki D et al. Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain. J Neurosci 37:2292-2304 (2017). PubMed: 28137966
- Llamosas N et al. Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons. Physiol Rep 5:N/A (2017). PubMed: 28196855
- Chittajallu R et al. Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells. Nat Commun 8:152 (2017). PubMed: 28751664
- Cellot G et al. Premature changes in neuronal excitability account for hippocampal network impairment and autistic-like behavior in neonatal BTBR T+tf/J mice. Sci Rep 6:31696 (2016). PubMed: 27526668