AB120271

DL-AP5 sodium salt, NMDA glutamate site antagonist

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(35 Publications)

DL-AP5 sodium salt (ab120271) is a NMDA receptor glutamate site antagonist. MW 219.11, Purity >99%.

- Cited in over 25 publications
- Available in different sizes to fit your experimental needs

查看别名

AMPA 1, AMPA-selective glutamate receptor 1, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243

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Chemical Structure - DL-AP5 sodium salt, NMDA glutamate site antagonist (AB120271)

Chemical Structure

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Chemical Structure - DL-AP5 sodium salt, NMDA glutamate site antagonist (AB120271)

2D chemical structure image of ab120271, DL-AP5 sodium salt, NMDA glutamate site antagonist

关键信息

CAS 号

1303993-72-7

纯度

>99%

形式

Solid

form

分子量

219.11 Da

分子式

C5H11NNaO5P

PubChem

52974251

属性

Synthetic

生化试剂名称

DL-AP5 Sodium salt

生物学描述

Competitive NMDA receptor glutamate site antagonist.

经典 SMILES

C(CC(C(=O)O)N)CP(=O)(O)[O-].[Na+]

InChi

InChI=1S/C5H12NO5P.Na/c6-4(5(7)8)2-1-3-12(9,10)11;/h4H,1-3,6H2,(H,7,8)(H2,9,10,11);/q;+1/p-1

InChiKey

KWRCYAPNGUCHOE-UHFFFAOYSA-M

IUPAC 名

sodium;(4-amino-4-carboxybutyl)-hydroxyphosphinate

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产品详情

Check out our range of NMDA glutamate antagonist biochemicals here

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

Store under desiccating conditions|The product can be stored for up to 12 months

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Dysfunction in GluR1 and associated AMPA receptors has been implicated in conditions like Alzheimer's disease and epilepsy. Alzheimer's disease exhibits decreased synaptic transmission and plasticity linked to impaired GluR1 function and its interactions with NMDA receptors. In epilepsy abnormal GluR1 activity may contribute to heightened neuronal excitability and seizure propagation. Targeting GluR1 or associated pathways offers potential for therapeutic interventions in these disorders possibly through drugs such as memantine and NBQX which modulate receptor activity.

Pathways

The GluR1-containing AMPA receptors participate significantly in the glutamatergic signaling pathway which is vital for fast excitatory synaptic transmission in the brain. This pathway also involves the NMDA receptors which work together with AMPA receptors to regulate synaptic plasticity and neuronal communication. Additionally the GluR1 interacts within the long-term potentiation (LTP) pathway contributing to the strengthening of synapses an essential mechanism underlying learning and memory.

Biological function summary

The GluR1 subunit is an essential component of the AMPA receptor complex which typically forms as a tetramer. This complex modulates synaptic strength and plasticity processes critical for learning and memory. The activity of AMPA receptors including those containing GluR1 is regulated by several auxiliary proteins and is essential for post-synaptic responses. The GluR1 subunit also interacts with other proteins such as TARPs which modulate its trafficking and channel properties.

Glutamate Receptor 1 (AMPA subtype) also known as GluR1 is a subunit of the AMPA receptor complex which mediates fast synaptic transmission in the central nervous system. It is an ionotropic receptor for glutamate functioning by opening ion channels to allow the flow of Na+ and Ca2+ ions across the cell membrane contributing to excitatory neurotransmission. The GluR1 subunit has a molecular mass of approximately 100 kDa. This receptor is commonly expressed in the brain regions such as the hippocampus and the cerebral cortex playing an important role in synaptic plasticity and memory formation.

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产品实验方案

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文献 (35)

Recent publications for all applications. Explore the full list and refine your search

Molecular autism 16:26 PubMed40241211

2025

Convergent depression of activity-dependent bulk endocytosis in rodent models of autism spectrum disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Bonnycastle,Mohammed Sarfaraz Nawaz,Peter C Kind,Michael A Cousin

Nature communications 15:8841 PubMed39396999

2024

Bi-directional allosteric pathway in NMDA receptor activation and modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Paula A Bender,Subhajit Chakraborty,Ryan J Durham,Vladimir Berka,Elisa Carrillo,Vasanthi Jayaraman

eLife 12: PubMed38470230

2024

Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Jun Zhu,Cai-Yun Deng,Liu Fan,Ya-Qian Wang,Hui Zhou,Hua-Tai Xu

EMBO reports 25:351-377 PubMed38177913

2024

An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Km Jörgensen,Alena Karnošová,Simone Mazzaferro,Oliver Rowley,Hsiao-Jou Cortina Chen,Sarah J Robbins,Sarah Christofides,Florian T Merkle,Lenka Maletínská,David Petrik

Nature communications 14:5285 PubMed37648685

2023

Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Bonnycastle,Katharine L Dobson,Eva-Maria Blumrich,Akshada Gajbhiye,Elizabeth C Davenport,Marie Pronot,Moritz Steinruecke,Matthias Trost,Alfredo Gonzalez-Sulser,Michael A Cousin

Cell reports 42:112699 PubMed37368752

2023

T-type Ca and persistent Na currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandra Topczewska,Elisabetta Giacalone,Wendy S Pratt,Michele Migliore,Annette C Dolphin,Mala M Shah

Current protocols 3:e786 PubMed37272700

2023

Differentiation, Transcriptomic Profiling, and Calcium Imaging of Human Hypothalamic Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Hsiao-Jou Cortina Chen,Simone Mazzaferro,Tian Tian,Iman Mali,Florian T Merkle

Journal of neurochemistry 166:248-264 PubMed37243578

2023

The phospho-regulated amphiphysin/endophilin interaction is required for synaptic vesicle endocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Christiana Kontaxi,Nawon Kim,Michael A Cousin

Communications biology 6:267 PubMed36918719

2023

Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Yi Chou,Xuhui Cao,Kuan-Chu Hou,Meng-Han Tsai,Chih-Yu Lee,Meng-Fai Kuo,Vin-Cent Wu,Hsin-Yi Huang,Schahram Akbarian,Sheng-Kai Chang,Chung-Yi Hu,Shu-Wha Lin,Hsien-Sung Huang

The Journal of neuroscience : the official journal of the Society for Neuroscience 43:2002-2020 PubMed36759195

2023

Epilepsy-Related CDKL5 Deficiency Slows Synaptic Vesicle Endocytosis in Central Nerve Terminals.

Applications

Unspecified application

Species

Unspecified reactive species

Christiana Kontaxi,Daniela Ivanova,Elizabeth C Davenport,Peter C Kind,Michael A Cousin

View all publications

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DL-AP5 sodium salt, NMDA glutamate site antagonist