Dihydrokainic acid，EAAT2 (GLT-1)抑制剂(ab120066)
Key features and details
- EAAT2 (GLT-1) inhibitor
- CAS Number: 52497-36-6
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Dihydrokainic acid，EAAT2 (GLT-1)抑制剂 -
描述
EAAT2 (GLT-1)抑制剂 -
别名
- DHK
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生物学描述
Selective, non-transportable inhibitor of glutamate transporter EAAT2 (GLT-1) (Ki = 23 μM). 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM).
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CAS编号
52497-36-6 -
化学结构
性能
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化学名称
(2S,3S,4R)-3-(Carboxymethyl)-4-isopropylpyrrolidine-2-carboxylic acid -
分子量
215.25 -
分子式
C10H17NO4 -
PubChem识别号
107883 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Dihydrokainic acid, EAAT2 (GLT-1) inhibitor (ab120066)2D chemical structure image of ab120066, Dihydrokainic acid, EAAT2 (GLT-1) inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (13)
ab120066 被引用在 13 文献中.
- Kong F et al. Repeated sevoflurane exposures inhibit neurogenesis by inducing the upregulation of glutamate transporter 1 in astrocytes. Eur J Neurosci 57:217-232 (2023). PubMed: 36440503
- Xu X et al. Yes-associated protein regulates glutamate homeostasis through promoting the expression of excitatory amino acid transporter-2 in astrocytes via β-catenin signaling. Glia 71:1197-1216 (2023). PubMed: 36617748
- Drumm MR et al. Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors. J Clin Invest 133:N/A (2023). PubMed: 37104042
- Zimmer ER et al. [18F]FDG PET signal is driven by astroglial glutamate transport. Nat Neurosci 20:393-395 (2017). PubMed: 28135241
- Armbruster M et al. Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex. J Neurosci 36:10404-10415 (2016). PubMed: 27707974