Cyclopiazonic acid from Penicillium grisefulvum，Ca2+-ATPase抑制剂(ab120300)
Key features and details
- Ca2+-ATPase inhibitor
- CAS Number: 18172-33-3
- Soluble in DMSO to 100 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Penicillium grisefulvum
概述
-
产品名称
Cyclopiazonic acid from Penicillium grisefulvum，Ca2+-ATPase抑制剂 -
描述
Ca2+-ATPase抑制剂 -
别名
- α-Cyclopiazonic acid
-
生物学描述
Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.
-
CAS编号
18172-33-3 -
化学结构
性能
-
化学名称
(6aR,11aS,11bR)-10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one -
分子量
336.39 -
分子式
C20H20N2O3 -
PubChem识别号
54682463 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 5 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(=O)C1=C(O)[C@H]5N(C1=O)C(C)(C)[C@@H]4Cc2cccc3ncc(c23)[C@@H]45 -
来源
Penicillium grisefulvum
-
研究领域
图片
-
Chemical Structure - Cyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor (ab120300)2D chemical structure image of ab120300, Cyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (8)
ab120300 被引用在 8 文献中.
- Zarate SM et al. Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum. NPJ Aging 9:5 (2023). PubMed: 37002232
- Rossi A et al. Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease. Cells 10:N/A (2021). PubMed: 33494218
- Gupta K et al. Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel. Biomaterials 259:120283 (2020). PubMed: 32827796
- Rossi A et al. Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models. Cell Rep 30:2332-2348.e10 (2020). PubMed: 32075767
- Fedeli C et al. PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis. Autophagy 15:2044-2062 (2019). PubMed: 30892128
- Clemens AM & Johnston D Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons. J Neurophysiol 111:1369-82 (2014). PubMed: 24381027
- Engbers JD et al. Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Proc Natl Acad Sci U S A 109:2601-6 (2012). PubMed: 22308379
- Qu L et al. Neuronal Fc-gamma receptor I mediated excitatory effects of IgG immune complex on rat dorsal root ganglion neurons. Brain Behav Immun 25:1399-407 (2011). PubMed: 21521651