Cycloheximide,蛋白synthesis抑制剂(ab120093)
Key features and details
- Protein synthesis inhibitor
- CAS Number: 66-81-9
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Cycloheximide,蛋白synthesis抑制剂 -
描述
蛋白synthesis抑制剂 -
生物学描述
Protein synthesis inhibitor. Antifungal antibiotic.
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CAS编号
66-81-9 -
化学结构
性能
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化学名称
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide -
分子量
281.35 -
分子式
C15H23NO4 -
PubChem识别号
6197 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C2CC(C[C@@H](O)[C@@H]1C[C@@H](C)C[C@H](C)C1=O)CC(=O)N2 -
来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120093于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - Cycloheximide, Protein synthesis inhibitor (ab120093)2D chemical structure image of ab120093, Cycloheximide, Protein synthesis inhibitor
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Functional Studies - Cycloheximide, Protein synthesis inhibitor (ab120093)Functional assays: Caspase 8 (active) FITC Staining Kit (ab65614)
Active caspase 8 in control Jurkat cells (10e6/mL) or cells treated for five hours with 10 ug/mL Cyclohexamide (CHX) (ab120093) or four hours with 25 ug/mL Mitomycin C (MitoC) (ab120797). Background signal subtracted, duplicates; +/- SD.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (27)
ab120093 被引用在 27 文献中.
- Wu T et al. KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions. Nat Biotechnol N/A:N/A (2024). PubMed: 38238480
- Zhou Y et al. Nudt21-mediated alternative polyadenylation of MZT1 3'UTR contributes to pancreatic cancer progression. iScience 27:108822 (2024). PubMed: 38303721
- Wu X et al. Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS. Acta Pharm Sin B 13:113-127 (2023). PubMed: 36815040
- Shang C et al. Nuclear NPM-ALK Protects Myc from Proteasomal Degradation and Contributes to Its High Expression in Cancer Stem-Like Cells in ALK-Positive Anaplastic Large Cell Lymphoma. Int J Mol Sci 24:N/A (2023). PubMed: 37762644
- Anadolu MN et al. Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association. J Neurosci 43:2440-2459 (2023). PubMed: 36849416