Compound 6877002, CD40-TRAF6 interaction inhibitor

关键信息

CAS 号

433249-94-6

纯度

>99%

形式

Solid

form

分子量

251.33 g/mol

分子式

C₁₇H₁₇NO

属性

Synthetic

溶解度

Soluble in ethanol to 100 mM

Soluble in DMSO to 100mM

生物学描述

CD40-TRAF6 interaction inhibitor. Small molecule that binds to TRAF6, blocking interactions with CD40. Suppresses CD40-induced IL-1β and IL-6 expression in primary macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in a mouse diet-induced obesity model.

同分异构的 SMILES

CC2CC(N/C=C/C(=O)C1CCCCC1)C(C)CC2

InChi

InChI=1/C17H17NO/c1-13-8-9-14(2)16(12-13)18-11-10-17(19)15-6-4-3-5-7-15/h3-12,18H,1-2H3/b11-10+

InChiKey

SARYOFMRLSHZFE-ZHACJKMWNA-N

IUPAC 名

3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one