CNQX disodium salt，AMPA / kainate拮抗剂(ab120044)
Key features and details
- AMPA / kainate antagonist; water soluble
- CAS Number: 479347-85-8
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
CNQX disodium salt，AMPA / kainate拮抗剂 -
描述
AMPA / kainate拮抗剂; water soluble -
生物学描述
Water soluble, potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.
Also available in simple stock solutions (ab144488) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
479347-85-8 -
化学结构
性能
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化学名称
1,2,3,4-Tetrahydro-7-nitro-2,3-dioxoquinoxaline-6-carbonitrile disodium -
分子量
276.12 -
分子式
C9H2N4Na2O4 -
PubChem识别号
2821 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Na+].[Na+].[O-][N+](=O)c1cc2nc([O-])c([O-])nc2cc1C#N -
来源
Synthetic
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研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab120044于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
图片
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Chemical Structure - CNQX disodium salt, AMPA / kainate antagonist (ab120044)2D chemical structure image of ab120044, CNQX disodium salt, AMPA / kainate antagonist
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Functional Studies - CNQX disodium salt, AMPA / kainate antagonist (ab120044)ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with CNQX disodium salt (ab120044), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of CNQX disodium salt, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120044 (CNQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (38)
ab120044 被引用在 38 文献中.
- Kontaxi C et al. Epilepsy-Related CDKL5 Deficiency Slows Synaptic Vesicle Endocytosis in Central Nerve Terminals. J Neurosci 43:2002-2020 (2023). PubMed: 36759195
- Vevea JD & Chapman ER Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic Ca2+ Homeostasis and the Synaptic Vesicle Cycle in Rat Hippocampal Axons. J Neurosci 43:3421-3438 (2023). PubMed: 36997314
- Katada Y et al. Starburst amacrine cells amplify optogenetic visual restoration through gap junctions. Mol Ther Methods Clin Dev 30:1-13 (2023). PubMed: 37324975
- Bonnycastle K et al. Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy. Nat Commun 14:5285 (2023). PubMed: 37648685
- Cummings KA et al. Control of fear by discrete prefrontal GABAergic populations encoding valence-specific information. Neuron 110:3036-3052.e5 (2022). PubMed: 35944526