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AB146128

cis-ACBD (1-Aminocyclobutane-1,3-dicarboxylic acid),L-glutamate uptake抑制剂

cis-ACBD (1-Aminocyclobutane-1,3-dicarboxylic acid), L-glutamate uptake inhibitor

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MW 159.14 Da. Selective, competitive L-glutamate uptake inhibitor (IC50 = 30 μM). Increases basal and potassium evoked D-aspartate release.

查看别名

15 LIPOXYGENASE RETICULOCYTE ARACHIDONATE, 15 LOX 1, 15 lipoxygenase 1, 15-LOX, ALOX15, AW490526, Arachidonate 15-lipoxygenase, Arachidonate omega-6 lipoxygenase, EB11, EIEE27, EPND, FESD, GRIN 2A, GRIN 2B, GRIN3A, GRIN3B, GluN1, GluN2A, GluN2C, GluN2D, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate [NMDA] receptor subunit epsilon-3, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor, Glutamate receptor ionotropic, Glutamate receptor ionotropic N methyl D aspartate 1, Glutamate receptor ionotropic N methyl D aspartate 2A, Glutamate receptor ionotropic N methyl D aspartate 3B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor ionotropic, N-methyl-D aspartate, subunit 1, Glutamate receptor ionotropic, NMDA 2C, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, N-methyl D-aspartate 2D, Glutamate receptor, ionotropic, NMDA2B (epsilon 2), Grin2c, Grin2d, LKS, LOG15, LOX15_HUMAN, MGC142178, MGC142180, MRD6, MRD8, N Methly D Aspartate Receptor Channel Subunit Epsilon 3, N methyl D asparate receptor channel subunit epsilon 2, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor channel, subunit epsilon 1, N methyl D aspartate receptor subunit 2A, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 2C, N methyl d aspartate receptor subunit 2D, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2C, N-methyl D-aspartate receptor subtype 2D, N-methyl-D-aspartate receptor, N-methyl-D-aspartate receptor subunit 3, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA 2D, NMDA NR2B, NMDA receptor 1, NMDA receptor subtype 2A, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDAR, NMDAR2C, NMDAR2D, NMDE1_HUMAN, NMDE2_HUMAN, NMDE3_HUMAN, NMDE4_HUMAN, NMDZ1_HUMAN, NR1, NR2A, NR2B, NR2C, NR2D, NR3, OTTHUMP00000041930, OTTHUMP00000160135, OTTHUMP00000174531, estrogen receptor binding CpG island, glutamate receptor ionotropic NMDA 2D, glutamate receptor ionotropic, NMDA 1, hNR 3, hNR2A

1 Images
Chemical Structure - cis-ACBD (1-Aminocyclobutane-1,3-dicarboxylic acid), L-glutamate uptake inhibitor (AB146128)
  • Chemical Structure

Lab

Chemical Structure - cis-ACBD (1-Aminocyclobutane-1,3-dicarboxylic acid), L-glutamate uptake inhibitor (AB146128)

2D chemical structure image of ab146128, cis-ACBD (1-Aminocyclobutane-1,3-dicarboxylic acid), L-glutamate uptake inhibitor

关键信息

CAS 号

73550-55-7

形式

Solid

form

分子量

159.14 Da

分子式

C<sub>6</sub>H<sub>9</sub>NO<sub>4</sub>

PubChem

1214

属性

Synthetic

溶解度

Soluble in 1eq. NaOH to 50 mM

生化试剂名称

1-Aminocyclobutane-1,3-dicarboxylic acid

生物学描述

Selective, competitive L-glutamate uptake inhibitor (IC50 = 30 μM). Increases basal and potassium evoked D-aspartate release.

经典 SMILES

C1C(CC1(C(=O)O)N)C(=O)O

InChi

InChI=1S/C6H9NO4/c7-6(5(10)11)1-3(2-6)4(8)9/h3H,1-2,7H2,(H,8,9)(H,10,11)

InChiKey

GGMYWPBNZXRMME-UHFFFAOYSA-N

IUPAC 名

1-aminocyclobutane-1,3-dicarboxylic acid

性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
Ambient
储存信息
The product can be stored for up to 12 months

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The N-methyl-D-aspartate (NMDA) receptors also known as NMDAR2A NMDAR2B GluN2C NMDAR1 NMDAR3A + 3B and GluN2D are types of glutamate receptors that are key players in synaptic transmission and plasticity. These receptors are tetrameric composed of different combinations of subunits that weigh approximately 135–175 kDa. They are primarily expressed in the central nervous system specifically in the brain regions such as the hippocampus and the cortex where they mediate excitatory synaptic transmission.
Biological function summary

NMDA receptors function as part of a larger receptor complex on the cell membrane playing a critical role in learning and memory. They act by permitting the flow of calcium ions into the neuron when activated by the neurotransmitter glutamate in conjunction with membrane depolarization. This ion influx triggers downstream signaling pathways that lead to long-term potentiation (LTP) a mechanism for synaptic strengthening.

Pathways

NMDA receptors are essential components of the glutamatergic signaling pathway. They participate in the calcium/calmodulin-dependent protein kinase (CaMK) pathway and interact with other proteins such as PSD-95 which organizes receptor complexes in the synapse. The pathways coordinate to modulate synaptic plasticity important for processes like neuronal development and adult neurogenesis.

NMDA receptors have strong links to conditions such as schizophrenia and Alzheimer's disease. Anomalies in NMDA receptor function can lead to disrupted synaptic transmission and cognitive defects associated with these diseases. For example in schizophrenia altered NMDA receptor activity may influence other associated proteins like dopamine receptors contributing to the disease's pathophysiology.

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