CHIR-124 (ab273615)
Key features and details
- Novel and potent Chk1 inhibitor
- CAS Number: 405168-58-3
- Purity: > 98%
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
CHIR-124 -
描述
Novel and potent Chk1抑制剂 -
生物学描述
Novel and potent Chk1 inhibitor (IC50 = 0.3 nM), 2,000-fold more potent than Chk2 (IC50 = 0.7 μM). Also, potently targets other kinases such as FLT3 (IC50 = 5.8 nM), PDGFR (IC50 = 6.6 nM), GSK-3 (IC50 = 23.3 nM) and Fyn (IC50 = 98.8 nM) .
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纯度
> 98% -
常规说明
For obtaining a higher solubility, please warm the tube at 37°C and shake in the ultrasonic bath for a while.
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CAS编号
405168-58-3 -
化学结构
性能
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化学名称
4-[(3S)-1-Azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6- chloro-2(1H)-quinolinone
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分子量
419.91 -
分子式
C23H22ClN5O -
PubChem识别号
135399748 -
存放说明
Shipped at room temperature. Store at -20°C. -
溶解度概述
Soluble in DMSO to 25 mM
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处理
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CN2CCC1[C@@H](C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5 -
来源
Synthetic
图片
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Chemical Structure - CHIR-124 (ab273615)
Chemical structure of CHIR-124, 405168-58-3
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab273615 尚未被引用在任何文献中。
