Charybdotoxin，K+ channel blocker (ab120269)
Key features and details
- K+ channel blocker
- CAS Number: 95751-30-7
- Soluble in water
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Charybdotoxin，K+ channel blocker -
描述
K+ channel blocker -
生物学描述
Blocks KCa1.1 (large conductance Ca2+ activated K+, Slo) channels in nanomolar concentrations as well as Kv1.2 (Kd = 14 nM) and Kv1.3 (Kd = 2.6 nM) channels.
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CAS编号
95751-30-7 -
化学结构
性能
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分子量
4295.89 -
分子式
C176H277N57O55S7 -
序列
XFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS (Modifications: X-1 = Glp; Disulfide bonds: 7-28, 13-33, 17-35) -
PubChem识别号
56842037 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
图片
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Chemical Structure - Charybdotoxin, K+ channel blocker (ab120269)2D chemical structure image of ab120269, Charybdotoxin, K+ channel blocker
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab120269 被引用在 4 文献中.
- Jonusaite S et al. Tissue-specific ionomotive enzyme activity and K+ reabsorption reveal the rectum as an important ionoregulatory organ in larval Chironomus riparius exposed to varying salinity. J Exp Biol 216:3637-48 (2013). PubMed: 23788699
- Zhang J et al. Role of the BK channel (KCa1.1) during activation of electrogenic K+ secretion in guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol 303:G1322-34 (2012). PubMed: 23064759
- Farrell SR et al. Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4. J Neurophysiol 104:1347-54 (2010). PubMed: 20573967
- Yang H & Xu-Friedman MA Developmental mechanisms for suppressing the effects of delayed release at the endbulb of Held. J Neurosci 30:11466-75 (2010). PubMed: 20739568