CGS 21680，A2A激动剂(ab120453)
Key features and details
- Potent, selective A2A agonist
- CAS Number: 124431-80-7
- Purity: > 96%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
CGS 21680，A2A激动剂 -
描述
Potent，selective A2A激动剂 -
生物学描述
Potent, selective A2A agonist (Ki = 23 nM). Hypotensive in vivo. Also delays motor performance deterioration and prevents reduction of brain weight in Huntington's disease model.
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纯度
> 96% -
CAS编号
124431-80-7 -
化学结构
性能
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化学名称
2-p-(2-Carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride -
分子量
535.99 -
分子式
C23H29N7O6.HCl -
PubChem识别号
44134621 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.O=C(O)CCc1ccc(cc1)CCNc3nc(N)c4ncn(C2OC(C(O)C2O)C(=O)NCC)c4n3 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - CGS 21680, A2A agonist (ab120453)2D chemical structure image of ab120453, CGS 21680, A2A agonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (6)
ab120453 被引用在 6 文献中.
- Soliño M et al. Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration. Front Pharmacol 13:840134 (2022). PubMed: 35387355
- Xu K et al. Adenosine from a biologic source regulates neutrophil extracellular traps (NETs). J Leukoc Biol 105:1225-1234 (2019). PubMed: 30907983
- Fujimoto K et al. Adenosine Attenuates Aortic Smooth Muscle Cell Calcification through A3 Adenosine Receptor. Tohoku J Exp Med 249:275-283 (2019). PubMed: 31875581
- Liu Y et al. Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine-induced blood brain barrier dysfunction via suppression of MLCK signaling pathway. Immun Inflamm Dis 6:72-80 (2018). PubMed: 29027376
- Li YF et al. Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy. Theranostics 8:5713-5730 (2018). PubMed: 30555576
- Kawamura M et al. Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy. Cardiovasc Diabetol 16:142 (2017). PubMed: 29096622