CGP 52432，GABAB拮抗剂(ab120330)
Key features and details
- Potent GABAB antagonist
- CAS Number: 139667-74-6
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
CGP 52432，GABAB拮抗剂 -
描述
Potent GABAB拮抗剂 -
生物学描述
Potent, selective GABAB antagonist (IC50 = 85 nM).
Also available in simple stock solutions (ab146709) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
139667-74-6 -
化学结构
性能
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化学名称
3-[[(3,4-Dichlorophenyl)methyl]amino]propyl(diethoxymethyl)phosphinic acid -
分子量
384.24 -
分子式
C15H24Cl2NO4P -
PubChem识别号
132252 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 10 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(CNCCCP(=O)(O)C(OCC)OCC)cc1Cl -
来源
Synthetic
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研究领域
图片
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Chemical Structure - CGP 52432, GABAB antagonist (ab120330)2D chemical structure image of ab120330, CGP 52432, GABAB antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (10)
ab120330 被引用在 10 文献中.
- Dorgans K et al. Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing. Elife 8:N/A (2019). PubMed: 31081751
- Kim S et al. Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse. Elife 7:N/A (2018). PubMed: 29578411
- Minge D et al. Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex 27:903-918 (2017). PubMed: 28119345
- Schauer C et al. Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle. J Neurophysiol 114:1008-21 (2015). PubMed: 26063780
- Hernández VM et al. Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus. J Neurosci 35:11830-47 (2015). PubMed: 26311767
- Hedrick T & Waters J Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors. J Neurophysiol 113:2195-209 (2015). PubMed: 25589590
- Russo G et al. Dynamics of action potential firing in electrically connected striatal fast-spiking interneurons. Front Cell Neurosci 7:209 (2013). PubMed: 24294191
- Valera AM et al. Adaptation of granule cell to Purkinje cell synapses to high-frequency transmission. J Neurosci 32:3267-80 (2012). PubMed: 22378898
- Min R & Nevian T Astrocyte signaling controls spike timing-dependent depression at neocortical synapses. Nat Neurosci 15:746-53 (2012). PubMed: 22446881
- Brager DH et al. Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndrome. Cell Rep 1:225-33 (2012). PubMed: 22662315
