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CGP 37157，Na+-Ca2+ exchange抑制剂(ab120012)

Submit a review Q&A (2)References (5)
Chemical Structure - CGP 37157, Na<sup>+</sup>-Ca<sup>2+</sup> exchange inhibitor (ab120012)

    Key features and details

    • Na+-Ca2+ exchange inhibitor
    • CAS Number: 75450-34-9
    • Soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      CGP 37157，Na+-Ca2+ exchange抑制剂

    • 描述

      Na+-Ca2+ exchange抑制剂

    • 生物学描述

      Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).

    • CAS编号

      75450-34-9

    • 化学结构

      Chemical Structure

    性能

    图片

    • Chemical Structure - CGP 37157, Na<sup>+</sup>-Ca<sup>2+</sup> exchange inhibitor (ab120012)
      Chemical Structure - CGP 37157, Na+-Ca2+ exchange inhibitor (ab120012)
      2D chemical structure image of ab120012, CGP 37157, Na+-Ca2+ exchange inhibitor

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (5)

    发表研究结果有使用 ab120012？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab120012 被引用在 5 文献中.

    • Wei K  et al. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther 8:22 (2023). PubMed: 36658134
    • Agarwal A  et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93:587-605.e7 (2017). PubMed: 28132831
    • Bondarenko AI  et al. Characterization of distinct single-channel properties of Ca(2+) inward currents in mitochondria. Pflugers Arch : (2013). PubMed: 23397170
    • Parnis J  et al. Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes. J Neurosci 33:7206-19 (2013). PubMed: 23616530
    • Jean-Quartier C  et al. Studying mitochondrial Ca(2+) uptake - a revisit. Mol Cell Endocrinol 353:114-27 (2012). PubMed: 22100614

    客户评价及客户问答

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    1-2 of 2 Abreviews or Q&A

    Question

    Our customer applied 6.17 ml of water into the vial and stored it forabout 1 hr in RT before use. (The lab temperature is 20C)
    She compared this product to other brand and Ascent doesn't have mention about light sensitive.
    Is this light sensitive product?

    Best regards,

    Read More
    Answer

    Thank you for your email.

    I spoke to the experts in the lab about the solubility issues with this product.

    They would like to make your customer aware that ab120012 has a low solubility in water. Therefore it may need prolonged stirring/agitation and warming to 40-50 degrees in order to get it into solution.

    It might also help if it is less concentrated, for example 1mM in water.

    I can confirm that we are not aware of any issues regarding light sensitivity.

    I hope these tips will help dissolve ab120012. Please let me know if the problem persists.

    Read More

    Question

    Dear technical team,

    Our customer received #ASC-012(ab120012, 10mg) two weeks ago and tried to dissolve it following instruction (water) but,

    it didn't dissolve at all.

    Lot#APN07045-4-2

    She has complaint this item.

    If you need information about this, let me know.


    Best regards,

    Read More
    Answer

    Thank you and your customer for taking the time to contact us. I am sorry to hear your customer has had difficulty disolving this product.

    Reviewing this case, I would like to offer some suggestions to help optimise the results from ab120012:

    1.) This product is soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM. Could you customer please let me know how much water was added to the 10mg? I can confirm that mistakes are easily done with these calculation from my own experience and your customer may want to double check.

    2.) Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. I also suggest to warm the reconstituted solution to 23C (room temperature) to enable full solvation

    We are happy to offer this technical support. In the event that a product is not functioning in the applications cited on the product data sheet (and the problem has been reported within 6 months of purchase), we will be pleased to provide a credit note, free of charge replacement or refund.

    I hope this information is helpful, thank you and your customer for your cooperation. Should the suggestions not improve the results, please do not hesitate to contact me again with the further requested details.

    Read More

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