Buparlisib (BKM120) (ab273384)
Key features and details
- In vitro PI3K inhibitor, in vivo tumor growth inhibitor
- CAS Number: 944396-07-0
- Purity: > 95%
Soluble in DMSO to 25 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Buparlisib (BKM120) -
描述
In vitro PI3K抑制剂, in vivo tumor growth抑制剂 -
别名
- NVP-BKM120
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生物学描述
Potent class I PI3K inhibitor, blocking both p110α and p110β (IC50 = 52 nM and 166 nM, respectively) in vitro. At 5 μM, prevents the growth of assorted cancer cell lines and inhibits tumor growth in vivo. Reduced effect against class III PI3K Vps34 and mammalian target of rapamycin (mTOR).
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纯度
> 95% -
常规说明
This product is manufactured by BioVision, an Abcam company and was previously called 2619 NVP-BKM120. 2619-25 is the same size as the 25 mg size of ab273384.
Protect from air.
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CAS编号
944396-07-0 -
化学结构
性能
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化学名称
5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine
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分子量
410.39 -
分子式
C18H21F3N6O2 -
PubChem识别号
16654980 -
存放说明
Shipped at 4°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. -
溶解度概述
Soluble in DMSO to 25 mM and in ethanol to 25 mM
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处理
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4 -
来源
Synthetic
图片
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Chemical Structure - Buparlisib (BKM120) (ab273384)
Chemical structure of Buparlisib (BKM120), 944396-07-0
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab273384 尚未被引用在任何文献中。