BRL 54443,激动剂at 5-HT1E and 5-HT1F receptors (ab120627)
Key features and details
- Selective agonist at 5-HT1E and 5-HT1F receptors
- CAS Number: 57477-39-1
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
BRL 54443,激动剂at 5-HT1E and 5-HT1F receptors -
描述
Selective激动剂at 5-HT1E and 5-HT1F receptors -
生物学描述
Potent, high affinity and selective agonist at 5-HT1E/1F receptors (pKi values are 8.7 and 8.9, respectively). Displays >30-fold selectivity for human 5-HT over dopamine receptors (pKi values are 7.2 (5-HT1A), 6.9 (5-HT1B), 7.2 (5-HT1D), 5.9 (5-HT2A), 7.0 (5-HT2B), 6.5 (5-HT2C), 6.3 (D2) and 6.2 (D3)).
-
纯度
> 99% -
CAS编号
57477-39-1 -
化学结构
性能
-
化学名称
5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole -
分子量
230.31 -
分子式
C14H18N2O -
PubChem识别号
2438 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CN1CCC(CC1)c2cnc3ccc(O)cc23 -
来源
Synthetic
-
研究领域
图片
-
Chemical Structure - BRL 54443, agonist at 5-HT1E and 5-HT1F receptors (ab120627)2D chemical structure image of ab120627, BRL 54443, agonist at 5-HT1E and 5-HT1F receptors
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (2)
ab120627 被引用在 2 文献中.
- Klein MT et al. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther 337:860-7 (2011). PubMed: 21422162
- McKune CM & Watts SW Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther 297:88-95 (2001). PubMed: 11259531