Brilliant Blue G，noncompetitive P2X7拮抗剂(ab120389)
Key features and details
- Potent, noncompetitive P2X7 antagonist
- CAS Number: 6104-58-1
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Brilliant Blue G，noncompetitive P2X7拮抗剂 -
描述
Potent，noncompetitive P2X7拮抗剂 -
别名
- Acid blue 90
- Coomassie® Brilliant Blue G
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生物学描述
Potent, non-competitive antagonist of rat and human P2X7 receptors (IC50 values are 10 and 200 nM, respectively). Displays >1000-fold selectivity over P2X4. IC50 values for inhibition of the other P2X receptors range from 2 to >30 µM. Rat and human P2X4 receptors show IC50 values of >10 and 3.2 µM, respectively.
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CAS编号
6104-58-1 -
化学结构
性能
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化学名称
N-[4-[[4-[(4-Ethoxyphenyl)amino]phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylene]-3-methyl-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium , inner salt, sodium salt -
分子量
854.02 -
分子式
C47H48N3NaO7S2 -
PubChem识别号
61363 -
存放说明
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 50 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC/[N+](Cc1cccc(c1)S([O-])(=O)=O)=C2/C=C/C(C(C)=C2)=C(/c4ccc(Nc3ccc(OCC)cc3)cc4)c5ccc(cc5C)N(Cc6cccc(c6)S(=O)(=O)O[Na])CC -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Brilliant Blue G, noncompetitive P2X7 antagonist (ab120389)2D chemical structure image of ab120389, Brilliant Blue G, noncompetitive P2X7 antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120389 被引用在 1 文献中.
- Jamali-Raeufy N et al. Combination therapy with dipeptidyl peptidase-4 and P2X7 purinoceptor inhibitors gives rise to antiepileptic effects in rats. J Chem Neuroanat 110:101855 (2020). PubMed: 33031915