BQ-123，ETA receptor拮抗剂(ab141005)
Key features and details
- Potent, selective ETA receptor antagonist
- CAS Number: 136553-81-6
- Purity: > 95%
- Soluble in water to 1.25 mg/ml
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
BQ-123，ETA receptor拮抗剂 -
描述
Potent，selective ETA receptor拮抗剂 -
生物学描述
Potent, selective ETA receptor antagonist (IC50 values are 7.3 and 18,000 nM for ETA and ETB endothelin receptors respectively). Some ability to cross the blood-brain barrier. Anti-ischemic activity in vivo.
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纯度
> 95% -
CAS编号
136553-81-6 -
化学结构
性能
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分子量
610.70 -
分子式
C31H42N6O7 -
序列
WDPVL (Modifications: Trp-1 = D-Trp; Asp-2 = D-Asp; Val-4 = D-Val; Cyclised: 1-5) -
PubChem识别号
443289 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 1.25 mg/ml -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - BQ-123, ETA receptor antagonist (ab141005)2D chemical structure image of ab141005, BQ-123, ETA receptor antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab141005 被引用在 4 文献中.
- Kobayashi Y et al. Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina. Dis Model Mech 14:N/A (2021). PubMed: 34664634
- Maayah ZH et al. Breast cancer diagnosis is associated with relative left ventricular hypertrophy and elevated endothelin-1 signaling. BMC Cancer 20:751 (2020). PubMed: 32787791
- Furukawa A et al. Endothelin Signaling Contributes to Modulation of Nociception in Early-stage Tongue Cancer in Rats. Anesthesiology 128:1207-1219 (2018). PubMed: 29461271
- Wu Q et al. CT perfusion imaging of cerebral microcirculatory changes following subarachnoid hemorrhage in rabbits: Specific role of endothelin-1 receptor antagonist. Brain Res 1701:196-203 (2018). PubMed: 30244111
