Birinapant (ab273619)
Key features and details
- Potent cIAP1 and XIAP antagonist
- CAS Number: 1260251-31-7
- Purity: > 98%
Soluble in DMSO to 50 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Birinapant -
描述
Potent cIAP1 and XIAP拮抗剂 -
别名
- TL32711
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生物学描述
Potent antagonist for cIAP1 (Kd <1 nM) and XIAP (Kd = 45 nM). Not only binds to the isolated BIR3 domains of cIAP1, cIAP2, XIAP but the single BIR domain of ML-IAP with high affinity and degrades TRAF2-bound cIAP1 and cIAP2 rapidly accordingly inhibiting the activation of TNF-mediated NF- kB. SMAC mimetic. Promotes caspase-8 formation.
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纯度
> 98% -
常规说明
For obtaining a higher solubility, please warm the tube at 37°C and shake in the ultrasonic bath for a while.
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CAS编号
1260251-31-7 -
化学结构
性能
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化学名称
(2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide
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分子量
806.94 -
分子式
C42H56F2N8O6 -
PubChem识别号
49836020 -
存放说明
Shipped at room temperature. Store at -20°C. -
溶解度概述
Soluble in DMSO to 50 mM and in ethanol to 50 mM
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处理
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[C@@H](C(=O)N1C[C@H](C[C@H]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[C@@H]6C[C@@H](CN6C(=O)[C@H](CC)NC(=O)[C@H](C)NC)O)O)NC(=O)[C@H](C)NC -
来源
Synthetic
图片
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Chemical Structure - Birinapant (ab273619)
Chemical structure of Birinapant, 1260251-31-7
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab273619 尚未被引用在任何文献中。
