Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online

beta-Amyloid多肽(1-40) (human) (ab120479)

Submit a review Q&A (3)References (4)
Chemical Structure - beta-Amyloid Peptide (1-40) (human) (ab120479)

    Key features and details

    • Amyloid beta (1-40) protein fragment. Implicated in Alzheimer's disease.
    • CAS Number: 131438-79-4

    • Soluble in DMSO to 1 mg/ml.

    • Form / State: Solid
    • Source: Synthetic

    概述

    • 产品名称

      beta-Amyloid多肽(1-40) (human)

    • 描述

      Amyloid beta (1-40)蛋白片段. Implicated in Alzheimer's disease.

    • CAS编号

      131438-79-4

    • 化学结构

      Chemical Structure

    性能

    图片

    • Chemical Structure - beta-Amyloid Peptide (1-40) (human) (ab120479)
      Chemical Structure - beta-Amyloid Peptide (1-40) (human) (ab120479)
      2D chemical structure image of ab120479, beta-Amyloid Peptide (1-40) (human)

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (4)

    发表研究结果有使用 ab120479？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab120479 被引用在 4 文献中.

    • Maiuolo J  et al. Hydroxytyrosol-Donepezil Hybrids Play a Protective Role in an In Vitro Induced Alzheimer's Disease Model and in Neuronal Differentiated Human SH-SY5Y Neuroblastoma Cells. Int J Mol Sci 24:N/A (2023). PubMed: 37686262
    • Arcone R  et al. Inhibition of Enzymes Involved in Neurodegenerative Disorders and Aβ1-40 Aggregation by Citrus limon Peel Polyphenol Extract. Molecules 28:N/A (2023). PubMed: 37687161
    • Kim SH  et al. Development of a Low-Molecular-Weight Aβ42 Detection System Using a Enzyme-Linked Peptide Assay. Biomolecules 11:N/A (2021). PubMed: 34944462
    • Zhang JX  et al. Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of ß-amyloid peptide. Alzheimers Res Ther 11:106 (2019). PubMed: 31847879

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    1-3 of 3 Abreviews or Q&A

    Question

    I would like to know if the products: ab120301 and ab120479 are in
    salt solution form.

    Read More
    Answer

    Thank you for contacting us.

    We can confirm that both of these peptide are lyophilised solids – in TFA salt form.

    For ab120301, reconstitute in100% DMSO which should re-suspend the peptide. This solution should be incubated at room temperature for 12 minutes, with occasional vortexing. The final solution should then be aliquoted into smaller volumes and stored at -80 °C. For a working solution, add 500-1000 µl of D-PBS (depending on the final concentration to be used) to the peptide stock solution and incubate for 2h at room temperature to allow for peptide aggregation.

    For ab120479, it can also be reconstituted in DMSO but for maximum biological activity, dilute in calcium-free PBS to a concentration of 1 mg/ml and incubate at 37°C for 4 days prior to use.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

    Read More

    Question

    The molecular weight is listed as 4329.86, but is this the weight of only the peptide or does this include the salt content?

    Read More
    Answer

    Thank you for your call yesterday and for your patience while I have been in touch with my colleagues in the lab.

    I have confirmed that the molecular weight listed (4329.86) is only the peptide and does not include the salt content. So, to calculate the molarity of a solution, you will need to also know the peptide content for the lot you are using (74.6% for batches the lots in stock). If you measure 1 mg of the product, only 0.746 mg is peptide, so you can calculate the molarity using that mass.

    I hope this information will be useful, but please let me know if you have any further questions or if there is anything else that we can do for you.

    Read More

    Question

    Can this product be dissolved in anything else other than DMSO, eg dH2O, PBS etc.

    Read More
    Answer

    Thank you for contacting Abcam.
    As we do not currently undertake our own research, I can offer advise based on published literature. Regarding the solubility of this compound, for maximum biological activity, dilute in calcium-free PBS to a concentration of 1 mg/ml and incubate at 370C for 4 days prior to use.

    Also find attacheda copy of the paper that we talked about on the telephone yesterday.

    I hope that this information is useful and if you have any further questions, please do not hesitate to contact me.

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
    For licensing inquiries, please contact partnerships@abcam.com