Belnacasan (VX-765) (ab273602)
Key features and details
- Potent and selective caspase-1 inhibitor
- CAS Number: 273404-37-8
- Purity: > 98%
Soluble in DMSO to 50 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Belnacasan (VX-765) -
描述
Potent and selective caspase-1 抑制剂 -
别名
- VX-765
-
生物学描述
Potent and selective inhibitor against caspase-1 with Ki of 0.8 nM. Orally absorbed. Also inhibits IL-1β release from both PBMCs and whole blood with IC50 of 0.67 μM and 1.9 μM, in vitro. Inhibits LPS-induced IL-1β production in collagen-induced arthritis mouse model, in vivo.
-
纯度
> 98% -
CAS编号
273404-37-8 -
化学结构
性能
-
化学名称
N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro5-oxo-3-furanyl]-L-prolinamide
-
分子量
508.99 -
分子式
C24H33ClN4O6 -
PubChem识别号
11398092 -
存放说明
Shipped at room temperature. Store at -20°C. -
溶解度概述
Soluble in DMSO to 50 mM and in ethanol to 50 mM
-
处理
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl -
来源
Synthetic
图片
-
Belnacasan (VX-765) (ab273602)
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
-
Datasheet download
文献 (0)
ab273602 尚未被引用在任何文献中。
