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AB142049

AZD1152-HQPA,Aurora B kinase抑制剂

AZD1152-HQPA, Aurora B kinase inhibitor

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(1 Publication)

AZD1152-HQPA (CAS No: 722544-51-6)(ab142049). Potent, selective Aurora B kinase inhibitor (IC50 = 0.37 nM). Induces apoptosis in vitro. Antitumor agent. Cell-permeable. Active in vitro and in vivo MW 507.6. Purity >99%.

- Larger volume format available upon request.

查看别名

Alpha-PAK, Beta PAK, CAM kinase II delta, CAMK 2, CAMK 2B, CAMK 2d, CAMK2G, CAMKA, CDC2L1, CDK11, CDKN1A, CaM kinase II, CaM kinase II alpha, CaM kinase II beta, CaM kinase II gamma, CaM kinase II subunit alpha, CaMK-II subunit alpha, Calcium / calmodulin dependent protein kinase II delta, Calcium/calmodulin dependent protein kinase II gamma, Calcium/calmodulin-dependent protein kinase II-alpha, Calcium/calmodulin-dependent protein kinase type II subunit alpha, Camk2a, Cell division cycle 2-like protein kinase 1, Cell division protein kinase 11B, EC 2.7.11.1, EC=2.7.11.22, GSD9C, Galactosyltransferase-associated protein kinase p58/GTA, Gamma-PAK, Germinal center kinase like kinase, Germinal center kinase-related protein kinase, ITSLRE serine/threonine protein kinase CDC2L1, KCC2A_HUMAN, KHS, Kinase homologous to SPS1/STE20, MAP4K3, MAPK/ERK kinase kinase kinase 3, MAPK/ERK kinase kinase kinase 5, MAPKKKK3, MEK kinase kinase 3, MEK kinase kinase 5, MEKKK 3, MEKKK 5, MRX30, MRX47, OPHN3, Oligophrenin 3, P21 (CDKN1A) activated kinase 2, P21 (CDKN1A) activated kinase 3, P21 protein (Cdc42/Rac) activated kinase 1, P21 protein (Cdc42/Rac) activated kinase 3, P21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related), P58, PAK alpha, PAK3beta, PAK65, PAKgamma, PHK gamma LT, PHK gamma T, PITSLREA, PK58, PSK C3, Phosphorylase b kinase gamma catalytic chain testis/liver isoform, Phosphorylase b kinase gamma catalytic chain, liver/testis isoform, Phosphorylase kinase catalytic subunit gamma 2, Phosphorylase kinase gamma subunit 2, Phosphorylase kinase subunit gamma 2, Phosphorylase kinase, gamma 2 (testis), Phosphorylase kinase, gamma 2 (testis/liver), RAB8IPL1, S6/H4 kinase, STE20 homolog, yeast, Serine/threonine protein kinase PAK 2, Serine/threonine protein kinase PAK 3, Serine/threonine protein kinase PHKG2, Serine/threonine-protein kinase PAK 1, TUBA1, TUBA1A, TUBA2, TUBA3, TUBA3C, TUBA4A, Tubulin, alpha 1a, Tubulin, alpha 3c, Tubulin, alpha 4a, bPAK, calcium/calmodulin-dependent protein kinase II beta, hPAK3, mitogen-activated protein kinase kinase kinase kinase 3, p21 activated kinase 3, p21 protein (Cdc42/Rac)-activated kinase 2, p21-activated kinase 1, p21-activated kinase 2, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast), p58 CLK 1, p65-PAK

1 Images
Chemical Structure - AZD1152-HQPA, Aurora B kinase inhibitor (AB142049)
  • Chemical Structure

Lab

Chemical Structure - AZD1152-HQPA, Aurora B kinase inhibitor (AB142049)

2D chemical structure image of ab142049, AZD1152-HQPA, Aurora B kinase inhibitor

关键信息

CAS 号

722544-51-6

纯度

>99%

形式

Solid

form

分子量

507.6 Da

分子式

C<sub>2</sub><sub>6</sub>H<sub>3</sub><sub>0</sub>FN<sub>7</sub>O<sub>3</sub>

PubChem

16007391

属性

Synthetic

溶解度

Soluble in DMSO to 25 mM

生化试剂名称

Azd-1152hqpa

生物学描述

Potent, selective Aurora B kinase inhibitor (IC50 = 0.37 nM). Induces apoptosis in vitro. Antitumor agent. Cell-permeable. Active in vitro and in vivo.

经典 SMILES

CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO

InChi

InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)

InChiKey

QYZOGCMHVIGURT-UHFFFAOYSA-N

IUPAC 名

2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide

产品详情

This product is manufactured by BioVision, an Abcam company and was previously called 1583 Aurora Kinase B Inhibitor (AZD1152-HQPA). 1583-25 is the same size as the 25 mg size of ab142049.

性能和储存信息

运输条件
Ambient - Can Ship with Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

产品实验方案

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell division 15:11 PubMed32973917

2020

XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Ellen Mitchell,Charlotte E L Mellor,Talveen S Purba
View all publications

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