Asenapine maleate，5-HT receptor拮抗剂and D2拮抗剂(ab120576)
Key features and details
- Multiple receptor antagonist. Antipsychotic agent.
- CAS Number: 85650-56-2
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
-
产品名称
Asenapine maleate，5-HT receptor拮抗剂and D2拮抗剂 -
描述
Multiple receptor拮抗剂. Antipsychotic agent. -
别名
- ASE
-
生物学描述
Novel, multiple receptor antagonist. Displays activity at 5-HT, dopamine, adrenoceptors and histamine receptors. (pKi values are 8.60 (5-HT1A), 8.40 (5-HT1B), 10.15 (5-HT2A), 9.75 (5-HT2B), 10.46 (5-HT2C), 8.84 (5-HT5A), 9.60 (5-HT6), 9.94 (5-HT7), 8.85 (D1), 8.90 (D2L), 8.84 (D2S), 9.38 (D3), 8.95 (D4), 8.93 (α1A), 8.9 (α2A), 9.49 (α2B), 8.91 (α2C), 9.00 (H1) and 8.21(H2)). Increases dopamine, norepinephrine and acetylcholine efflux. Antipsychotic in vivo.
-
CAS编号
85650-56-2 -
化学结构
性能
-
化学名称
trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole maleate -
分子量
401.85 -
分子式
C17H16ClNO.C4H4O4 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
来源
Synthetic
-
研究领域
图片
-
Chemical Structure - Asenapine maleate, 5-HT receptor antagonist and D2 antagonist (ab120576)2D chemical structure image of ab120576, Asenapine maleate, 5-HT receptor antagonist and D2 antagonist
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (0)
ab120576 尚未被引用在任何文献中。