Apigenin，Anticancer agent (ab120141)
Key features and details
- Anticancer agent
- CAS Number: 520-36-5
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Apigenin，Anticancer agent -
描述
Anticancer agent -
生物学描述
Plant flavone. Antioxidant, anti-inflammatory and anticancer properties. Effects a wide range of molecular targets including caspases, fatty acid synthase, topoisomerase and nuclear factor-κB.
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纯度
> 98% -
CAS编号
520-36-5 -
化学结构
性能
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化学名称
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one -
分子量
270.24 -
分子式
C15H10O5 -
PubChem识别号
5280443 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Oc1ccc(cc1)C3=CC(=O)c2c(cc(O)cc2O)O3 -
来源
Synthetic
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研究领域
图片
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Chemical Structure - Apigenin, Anticancer agent (ab120141)2D chemical structure image of ab120141, Apigenin, Anticancer agent
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Functional Studies - Apigenin, Anticancer agent (ab120141)Bauer et al PLoS One. 2017 Apr 25;12(4):e0175558. doi: 10.1371/journal.pone.0175558. eCollection 2017. Fig 2. Reproduced under the Creative Commons license https://creativecommons.org/publicdomain/zero/1.0/(A-D). The release of cytokines as assessed using Human Cytokine Array C1000 membranes from MDA-MB-231 cells ± TNFα ± Apigenin. [A] Ctrls, [B] TNFα-treated (40ng/mL) [C] Apigenin (40μM) and [D] TNFα-treated (40ng/mL) + Apigenin (40μM) co-treated cells.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (1)
ab120141 被引用在 1 文献中.
- Bauer D et al. Apigenin inhibits TNFa/IL-1a-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. PLoS One 12:e0175558 (2017). PubMed: 28441391