Aphidicolin，DNA polymerase alpha，delta and epsilon抑制剂(ab142400)
Key features and details
- DNA polymerase α, δ and ε inhibitor
- CAS Number: 38966-21-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Phoma sp.
概述
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产品名称
Aphidicolin，DNA polymerase alpha，delta and epsilon抑制剂 -
描述
DNA polymerase α，δ and ε抑制剂 -
纯度
> 98% -
CAS编号
38966-21-1 -
化学结构
性能
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化学名称
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol -
分子量
338.48 -
分子式
C20H34O4 -
PubChem识别号
457964 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O -
来源
Phoma sp.
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研究领域
图片
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Chemical Structure - Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor (ab142400)2D chemical structure image of ab142400, Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (11)
ab142400 被引用在 11 文献中.
- Sun Y et al. RAD21 is the core subunit of the cohesin complex involved in directing genome organization. Genome Biol 24:155 (2023). PubMed: 37381036
- Shi Z et al. Activation of P53 pathway contributes to Xenopus hybrid inviability. Proc Natl Acad Sci U S A 120:e2303698120 (2023). PubMed: 37186864
- Kovacs MT et al. DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Mol Cell 83:3659-3668.e10 (2023). PubMed: 37832547
- Grow EJ et al. p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. Nat Genet 53:1207-1220 (2021). PubMed: 34267371
- Wang H et al. Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Oncogene 39:2905-2920 (2020). PubMed: 32029902