AG 490，JAK2/3抑制剂(ab120950)
Key features and details
- JAK2/3 inhibitor
- CAS Number: 133550-30-8
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
AG 490，JAK2/3抑制剂 -
描述
JAK2/3抑制剂 -
生物学描述
JAK2/3 inhibitor (IC50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo.
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纯度
> 99% -
CAS编号
133550-30-8 -
化学结构
性能
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化学名称
(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide -
分子量
294.31 -
分子式
C17H14N2O3 -
PubChem识别号
5328779 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- JAK/STAT signaling
- STAT
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- JAK/STAT signaling
- STAT
- Inhibitors
图片
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Chemical Structure - AG 490, JAK2/3 inhibitor (ab120950)2D chemical structure image of ab120950, AG 490, JAK2/3 inhibitor
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (5)
ab120950 被引用在 5 文献中.
- Zhang Z et al. Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction. J Mol Endocrinol 66:259-272 (2021). PubMed: 33729996
- Li HN et al. Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-a through activating ERK, p38 MAPK, and JAK2/STAT3. J Neuroinflammation 18:150 (2021). PubMed: 34225736
- Wang Y & Li Y MiR-29c inhibits HCV replication via activation of type I IFN response by targeting STAT3 in JFH-1-infected Huh7 cells. RSC Adv 8:8164-8172 (2018). PubMed: 35542013
- Guo YJ et al. Red nucleus interleukin-1ß evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways. J Neurosci Res 96:1847-1861 (2018). PubMed: 30216497
- Zeng Y et al. Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis. Carcinogenesis 35:2244-53 (2014). PubMed: 24925029