AB120287

A23187 (Calcimycin), Ca2+ ionophore

Name: A23187 (Calcimycin), Ca2+ ionophore (ab120287)| Abcam中文官网
Brand: Abcam Limited
SKU: AB120287
Price: 1704 CNY
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(10 Publications)

MW 523.6 Da, Purity >98%. A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria.

查看别名

ASRT2, BAP1_HUMAN, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BRCA1-associated protein 1, Cerebral protein 13, Cerebral protein 6, DKFZp686N04275, FLJ35406, FLJ37180, G protein coupled receptor 154, G protein coupled receptor PGR14, G protein coupled receptor for asthma susceptibility, GPR 154, GPRA, HUCEP 13, Hucep 6, KIAA0272, MVTR, NPSR, Neuropeptide S receptor, Neuropeptide S receptor 1, PGR 14, TPDS, UCHL2, Ubiquitin carboxy terminal hydrolase, Ubiquitin carboxyl-terminal hydrolase BAP1, VRR 1, Vasopressin receptor related receptor 1, nps receptor

1 Images

Chemical Structure - A23187 (Calcimycin), Ca2+ ionophore (AB120287)

Chemical Structure

Lab

Chemical Structure - A23187 (Calcimycin), Ca2+ ionophore (AB120287)

2D chemical structure image of ab120287, A23187 (Calcimycin), Ca2+ ionophore

关键信息

CAS 号

52665-69-7

纯度

>98%

形式

Solid

form

来源

Steptomyces chartreusensis

分子量

523.6 Da

分子式

C29H37N3O6

PubChem

11957499

属性

Native

溶解度

Soluble in DMSO to 100 mM (with heating)

生化试剂名称

Calcimycin

生物学描述

A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria.

经典 SMILES

CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC

同分异构的 SMILES

C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)C3=CC=CN3)C)C)O[C@@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC

InChi

InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1

InChiKey

HIYAVKIYRIFSCZ-CYEMHPAKSA-N

IUPAC 名

5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid

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性能和储存信息

运输条件

Ambient - Can Ship with Ice

储存信息

Store under desiccating conditions|The product can be stored for up to 12 months

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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文献 (10)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed38139101

2023

A Comparative Study of Different Protocols for Isolation of Murine Neutrophils from Bone Marrow and Spleen.

Applications

Unspecified application

Species

Unspecified reactive species

Khetam Sounbuli,Ludmila A Alekseeva,Oleg V Markov,Nadezhda L Mironova

Journal of extracellular vesicles 12:e12354 PubMed37553837

2023

Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Thach Tuan Pham,Anh Hong Le,Cong Phi Dang,Suet Yen Chong,Dang Vinh Do,Boya Peng,Migara Kavishka Jayasinghe,Hong Boon Ong,Dong Van Hoang,Roma Anne Louise,Yuin-Han Loh,Han Wei Hou,Jiong-Wei Wang,Minh Tn Le

STAR protocols 3:101870 PubMed36595929

2022

Protocol to analyze lipid asymmetry in the plasma membrane.

Applications

Unspecified application

Species

Unspecified reactive species

Yugo Miyata,Katsumori Segawa

Experimental and therapeutic medicine 21:353 PubMed33732326

2021

Differentiation of HL-60 cells in serum-free hematopoietic cell media enhances the production of neutrophil extracellular traps.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Guo,Fei Gao,Qian Wang,Kang Wang,Shanshan Pan,Zhenzhen Pan,Shiyao Xu,Ling Li,Deyu Zhao

Biomaterials 259:120283 PubMed32827796

2020

Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel.

Applications

Unspecified application

Species

Unspecified reactive species

Kapish Gupta,Inn Chuan Ng,Gowri Manohari Balachander,Binh P Nguyen,Lisa Tucker-Kellogg,Boon Chuan Low,Hanry Yu

Journal of pharmaceutical analysis 10:466-472 PubMed33133730

2020

Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Dong,Xiao-Rong Li,Jia Li,Yi Zang,Xin Li

Cell reports 29:4144-4158.e7 PubMed31851939

2019

Discrimination of Dormant and Active Hematopoietic Stem Cells by G Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.

Applications

Unspecified application

Species

Unspecified reactive species

Tsuyoshi Fukushima,Yosuke Tanaka,Fiona K Hamey,Chih-Hsiang Chang,Toshihiko Oki,Shuhei Asada,Yasutaka Hayashi,Takeshi Fujino,Taishi Yonezawa,Reina Takeda,Kimihito Cojin Kawabata,Tomofusa Fukuyama,Terumasa Umemoto,Keiyo Takubo,Hitoshi Takizawa,Susumu Goyama,Yasushi Ishihama,Hiroaki Honda,Berthold Göttgens,Toshio Kitamura

Biochimica et biophysica acta. Molecular cell rese 1864:947-956 PubMed28254579

2017

Resveratrol-induced autophagy is dependent on IPRs and on cytosolic Ca.

Applications

Unspecified application

Species

Unspecified reactive species

Tomas Luyten,Kirsten Welkenhuyzen,Gemma Roest,Elzbieta Kania,Liwei Wang,Mart Bittremieux,David I Yule,Jan B Parys,Geert Bultynck

Journal of dermatological science 76:173-9 PubMed25306296

2014

Cathelicidin peptide LL-37 increases UVB-triggered inflammasome activation: possible implications for rosacea.

Applications

Unspecified application

Species

Unspecified reactive species

Suzanna Salzer,Sonja Kresse,Yoji Hirai,Sarah Koglin,Markus Reinholz,Thomas Ruzicka,Jürgen Schauber

Biochimica et biophysica acta 1843:2592-602 PubMed24983772

2014

Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Wang,Lingao Ju,Jiadong Fan,Yuan Zhu,Xiaolan Liu,Kun Zhu,Min Wu,Lianyun Li

View all publications

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A23187 (Calcimycin), Ca2+ ionophore